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Tbio
ZNF462
Zinc finger protein 462

Protein Summary
Description
Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization (PubMed:20219459, PubMed:21570965). Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG (PubMed:21570965). By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA (By similarity). Regulates neuronal development and neural cell differentiation (PubMed:21570965). The protein encoded by this gene belongs to C2H2-type zinc finger family of proteins. It contains multiple C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277225
  • ENSP00000277225
  • ENSG00000148143
  • ENST00000441147
  • ENSP00000397306

Symbol
  • KIAA1803
  • ZFPIP
  • Zfp462
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.75
transcription factor perturbation
0.74
transcription factor binding site profile
0.67
histone modification site profile
0.64
ligand (protein) perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.57   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.57   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
89.9
mathematical ability
3
2
3
89.4
self reported educational attainment
1
1
1
77.2
body height
2
2
1
5.3
76.3
refractive error measurement
1
1
1
69.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
89.9
mathematical ability
3
89.4
self reported educational attainment
1
77.2
body height
1
5.3
76.3
refractive error measurement
1
69.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (38)
1 – 10 of 38
WIZ
Tbio
Family: TF
Novelty: 0.04458547
p_int: 0.99999903
p_ni: 9.7e-7
Score: 0.347
Data Source: BioPlex,STRINGDB
EHMT1
Tchem
Family: Epigenetic
Novelty: 0.00821799
p_int: 0.999996651
p_ni: 0.000003349
Score: 0.324
Data Source: BioPlex,STRINGDB
EHMT2
Tchem
Family: Epigenetic
Novelty: 0.00262578
p_int: 0.999985685
p_ni: 0.000014314
p_wrong: 2e-9
Score: 0.579
Data Source: BioPlex,STRINGDB
D2HGDH
Tbio
Family: Enzyme
Novelty: 0.04618268
p_int: 0.999668531
p_ni: 0.000331467
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
ZNF644
Tbio
Family: TF
Novelty: 0.12816167
p_int: 0.999615357
p_ni: 0.000384643
Score: 0.171
Data Source: BioPlex,STRINGDB
CBX5
Tbio
Family: Epigenetic
Novelty: 0.00653413
p_int: 0.989673442
p_ni: 0.010326558
Score: 0.283
Data Source: BioPlex,STRINGDB
VAX1
Tbio
Family: TF
Novelty: 0.03227839
Score: 0.905
Data Source: STRINGDB
ASXL2
Tbio
Family: Epigenetic
Novelty: 0.04277784
Score: 0.905
Data Source: STRINGDB
ZNF483
Tdark
Family: TF
Novelty: 0.39891191
Score: 0.756
Data Source: STRINGDB
RPRD2
Tdark
Novelty: 0.45063764
Score: 0.734
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.57

PubMed score by year
PubTator Score  3.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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