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Tbio
MAML3
Mastermind-like protein 3

Protein Summary
Description
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000509479
  • ENSP00000421180
  • ENSG00000196782

Symbol
  • KIAA1816
  • GDN
  • MAM2
  • CAGH3
  • ERDA3
  • MAM-2
  • TNRC3
  • mam-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
microRNA
0.79
transcription factor
0.67
cell line
0.56
cell type or tissue
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.84   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
6
6
98.3
smoking initiation
2
2
2
96.1
smoking status measurement
2
1
2
94.4
cognitive function measurement
3
2
3
92.7
body mass index
2
1
2
87.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
98.3
smoking initiation
2
96.1
smoking status measurement
2
94.4
cognitive function measurement
3
92.7
body mass index
2
87.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mastermind like transcriptional coactivator 3
VGNC:13023
471311
Macaque
mastermind like transcriptional coactivator 3
697863
Mouse
MGI:2389461
433586
Dog
mastermind like transcriptional coactivator 3
VGNC:50422
102154734
Horse
mastermind like transcriptional coactivator 3
VGNC:19905
100063201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mastermind like transcriptional coactivator 3
Macaque
mastermind like transcriptional coactivator 3
Mouse
Dog
mastermind like transcriptional coactivator 3
Horse
mastermind like transcriptional coactivator 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JK9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (134)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Developmental Biology
Disease
Diseases of signal transduction
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (99)
1 – 10 of 99
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.999
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.999
Data Source: Reactome,STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.999
Data Source: Reactome,STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.999
Data Source: Reactome,STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.999
Data Source: Reactome,STRINGDB
MAML1
Tbio
Novelty: 0.01302751
Score: 0.999
Data Source: STRINGDB
MAMLD1
Tbio
Novelty: 0.01681081
Score: 0.973
Data Source: STRINGDB
MAML2
Tbio
Novelty: 0.00836375
Score: 0.935
Data Source: STRINGDB
HES5
Tbio
Family: TF
Novelty: 0.00565225
Score: 0.923
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.84

PubMed score by year
PubTator Score  15.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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