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Tbio
ELMO2
Engulfment and cell motility protein 2

Protein Classes
Protein Summary
Description
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290246
  • ENSP00000290246
  • ENSG00000062598
  • ENST00000372176
  • ENSP00000361249
  • ENST00000396391
  • ENSP00000379673

Symbol
  • CED12A
  • KIAA1834
  • VMPI
  • CED12
  • CED-12
  • ELMO-2
  • Ced-12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
protein domain
0.85
cell type or tissue
0.64
microRNA
0.64
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.76   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
3
3
53.7
body mass index
1
1
1
49.5
body height
1
1
1
35
diet measurement
1
1
1
30.2
eye movement measurement
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
53.7
body mass index
1
49.5
body height
1
35
diet measurement
1
30.2
eye movement measurement
1
3.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 2
VGNC:6101
458299
Macaque
engulfment and cell motility 2
707316
Mouse
MGI:2153045
140579
Dog
engulfment and cell motility 2
VGNC:40310
477251
Horse
engulfment and cell motility 2
VGNC:17530
100056774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
engulfment and cell motility 2
Macaque
engulfment and cell motility 2
Mouse
Dog
engulfment and cell motility 2
Horse
engulfment and cell motility 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Reactome
Regulation of actin dynamics for phagocytic cup formation
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Regulation of actin dynamics for phagocytic cup formation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (96)
1 – 10 of 96
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.999999994
p_ni:  5e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
DOCK4
Tbio
Novelty:  0.02356655
p_int:  0.99999995
p_ni:  5e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
ELMO1
Tbio
Novelty:  0.01598587
p_int:  0.99999984
p_ni:  1.6e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999328
p_ni:  6.71e-7
Score:  0.631
Data Source:  BioPlex,STRINGDB
ELMO3
Tbio
Novelty:  0.05985405
p_int:  0.99995251
p_ni:  0.00004749
Score:  0.973
Data Source:  BioPlex,STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
p_int:  0.99919353
p_ni:  0.00080647
Score:  0.705
Data Source:  BioPlex,STRINGDB
ERMAP
Tbio
Novelty:  0.04270359
p_int:  0.994858391
p_ni:  0.005135329
p_wrong:  0.00000628
Data Source:  BioPlex
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.991641024
p_ni:  0.008348562
p_wrong:  0.000010414
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.904335073
p_ni:  0.095372977
p_wrong:  0.00029195
Score:  0.24
Data Source:  BioPlex,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.785739902
p_ni:  0.015452462
p_wrong:  0.198807636
Data Source:  BioPlex
Publication Statistics
PubMed Score  23.76

PubMed score by year
PubTator Score  9.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer