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Tbio
RADIL
Ras-associating and dilute domain-containing protein

Protein Summary
Description
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.69
gene perturbation
0.65
transcription factor binding site profile
0.62
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.79   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.79   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
FLRT1
Tdark
Novelty:  0.23047852
p_int:  0.999957918
p_ni:  0.000041995
p_wrong:  8.7e-8
Score:  0.249
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.99991259
p_ni:  0.000087377
p_wrong:  3.2e-8
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.999713728
p_ni:  0.000286254
p_wrong:  1.8e-8
Data Source:  BioPlex
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.99966657
p_ni:  0.000333428
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
CD83
Tbio
Novelty:  0.00138653
p_int:  0.997491915
p_ni:  0.002439402
p_wrong:  0.000068683
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.792573993
p_ni:  0.000826822
p_wrong:  0.206599184
Score:  0.165
Data Source:  BioPlex,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.8
Data Source:  STRINGDB
RRAS2
Tbio
Family:  Enzyme
Novelty:  0.01870067
Score:  0.667
Data Source:  STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.659
Data Source:  STRINGDB
ARHGAP29
Tbio
Family:  Enzyme
Novelty:  0.05574918
Score:  0.646
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
1
1
24.5
apolipoprotein A 1 measurement
1
1
1
21.5
parental longevity
1
1
1
17.8
electrocardiography
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosquito bite reaction itch intensity measurement
1
24.5
apolipoprotein A 1 measurement
1
21.5
parental longevity
1
17.8
electrocardiography
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap associating with DIL domain
VGNC:8743
463241
Macaque
Rap associating with DIL domain
700979
Mouse
MGI:2443088
231858
Rat
RGD:1306155
304299
Horse
Rap associating with DIL domain
VGNC:22152
100060713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap associating with DIL domain
Macaque
Rap associating with DIL domain
Mouse
Rat
Horse
Rap associating with DIL domain
Publication Statistics
PubMed Score 6.79
PubMed score by year
PubTator Score 0.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title