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Tbio
VCPIP1
Deubiquitinating protein VCIP135

Protein Summary
Description
Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310421
  • ENSP00000309031
  • ENSG00000175073

Symbol
  • KIAA1850
  • VCIP135
  • DUBA3
  • VCIP135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.83
transcription factor binding site profile
0.78
virus perturbation
0.76
cell line
0.66
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
CNKSR3
Tbio
Family:  Enzyme
Novelty:  0.14999986
p_int:  0.999999424
p_ni:  5.59e-7
p_wrong:  1.7e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
GAN
Tbio
Novelty:  0.01069743
p_int:  0.999993294
p_ni:  0.000006697
p_wrong:  9e-9
Data Source:  BioPlex
HRASLS5
Tchem
Family:  Enzyme
Novelty:  0.02885442
p_int:  0.999989113
p_ni:  0.000010887
Score:  0.393
Data Source:  BioPlex,STRINGDB
LRCH3
Tdark
Novelty:  1.02650989
p_int:  0.999975326
p_ni:  0.000024671
p_wrong:  2e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.998416018
p_ni:  0.001583981
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.997026484
p_ni:  0.002973516
Data Source:  BioPlex
MAF1
Tbio
Family:  Enzyme
Novelty:  0.01060279
p_int:  0.996548844
p_ni:  0.003451155
Score:  0.196
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.99473839
p_ni:  0.005261609
p_wrong:  1e-9
Score:  0.168
Data Source:  BioPlex,STRINGDB
DND1
Tbio
Novelty:  0.0287312
p_int:  0.981358066
p_ni:  0.018641934
Score:  0.196
Data Source:  BioPlex,STRINGDB
RNF41
Tbio
Family:  Enzyme
Novelty:  0.01953473
p_int:  0.965766323
p_ni:  0.034233567
p_wrong:  1.1e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
3
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
3
29
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein interacting protein 1
VGNC:10487
472782
Macaque
valosin containing protein interacting protein 1
703582
Mouse
MGI:1917925
70675
Rat
RGD:708520
286761
Dog
valosin containing protein interacting protein 1
VGNC:48244
486980
Species
Name
OMA
EggNOG
Inparanoid
Chimp
valosin containing protein interacting protein 1
Macaque
valosin containing protein interacting protein 1
Mouse
Rat
Dog
valosin containing protein interacting protein 1
Publication Statistics
PubMed Score 10.48
PubMed score by year
PubTator Score 8.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title