Tbio VCPIP1 Deubiquitinating protein VCIP135

Protein Summary

Description

Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.

Uniprot Accession IDs

• Q96JH7
• Q504T4
• Q86T93
• Q86W01
• Q8N3A9
• Q9H5R8

Gene Name

• VCPIP1

Ensembl ID

• ENST00000310421
• ENSP00000309031
• ENSG00000175073

Symbol

• KIAA1850
• VCIP135
• DUBA3
• VCIP135

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.83
transcription factor binding site profile	0.78
virus perturbation	0.76
cell line	0.66
histone modification site profile	0.65

Protein Classes

PANTHER Classes

Protein / ... / Cysteine Protease / Deubiquitinating Protein Vcip135

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Deubiquitinating Protein Vcip135

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.56   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.56   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0