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Tbio
VPS50
Syndetin

Protein Summary
Description
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251739
  • ENSP00000251739
  • ENSG00000004766
  • ENST00000305866
  • ENSP00000307666
  • ENST00000544910
  • ENSP00000443104

Symbol
  • CCDC132
  • KIAA1861
  • VPS54L
  • CCDC132
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
61.4
triglyceride measurement
1
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
61.4
triglyceride measurement
2
35
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS50, EARP/GARPII complex subunit
VGNC:8788
463538
Macaque
VPS50, EARP/GARPII complex subunit
701991
Mouse
MGI:1920538
73288
Rat
RGD:1304751
312083
Dog
VPS50, EARP/GARPII complex subunit
VGNC:48294
475228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS50, EARP/GARPII complex subunit
Macaque
VPS50, EARP/GARPII complex subunit
Mouse
Rat
Dog
VPS50, EARP/GARPII complex subunit
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JG6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (54)
1 – 10 of 54
VPS53
Tbio
Novelty:  0.07513165
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.999999999
p_ni:  1e-9
Score:  0.949
Data Source:  BioPlex,STRINGDB
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999999901
p_ni:  9.9e-8
Data Source:  BioPlex
VPS54
Tbio
Novelty:  0.04428383
p_int:  0.999999497
p_ni:  5.02e-7
p_wrong:  1e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
VPS52
Tbio
Novelty:  0.01439614
p_int:  0.99998195
p_ni:  0.00001805
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999450479
p_ni:  0.000549521
Score:  0.822
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999410512
p_ni:  0.000589488
Score:  0.314
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999152718
p_ni:  0.000847282
Score:  0.498
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99849801
p_ni:  0.00150199
Score:  0.211
Data Source:  BioPlex,STRINGDB
VPS51
Tbio
Novelty:  0.01766125
p_int:  0.961664904
p_ni:  0.038335096
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.03

PubMed score by year
PubTator Score  1.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer