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Tbio
MAP6
Microtubule-associated protein 6

Protein Summary
Description
Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304771
  • ENSP00000307093
  • ENSG00000171533
  • ENST00000434603
  • ENSP00000415108
  • ENST00000526740
  • ENSP00000434278

Symbol
  • KIAA1878
  • STOP
  • MTAP6
  • MAP6-N
  • N-STOP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
PubMedID
0.7
cellular component
0.63
cell line
0.58
microRNA
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
5
10
96.2
body height
9
4
11
92.8
BMI-adjusted hip circumference
3
3
3
77.1
BMI-adjusted waist circumference
3
2
3
76.2
hemoglobin measurement
2
2
2
73.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
96.2
body height
11
92.8
BMI-adjusted hip circumference
3
77.1
BMI-adjusted waist circumference
3
76.2
hemoglobin measurement
2
73.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 6
VGNC:3108
451428
Macaque
microtubule associated protein 6
696223
Mouse
MGI:1201690
17760
Rat
RGD:61804
29457
Dog
microtubule associated protein 6
VGNC:42986
476803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 6
Macaque
microtubule associated protein 6
Mouse
Rat
Dog
microtubule associated protein 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JE9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (56)
1 – 10 of 56
MAP9
Tbio
Novelty:  0.08883282
Score:  0.811
Data Source:  STRINGDB
MAP10
Tbio
Novelty:  0.10409728
Score:  0.786
Data Source:  STRINGDB
MAP7
Tbio
Novelty:  0.01976296
Score:  0.785
Data Source:  STRINGDB
ASTN1
Tbio
Novelty:  0.03247697
Score:  0.765
Data Source:  STRINGDB
MAP1B
Tchem
Novelty:  0.00215274
Score:  0.748
Data Source:  STRINGDB
ZDHHC13
Tbio
Family:  Enzyme
Novelty:  0.17442533
Score:  0.743
Data Source:  STRINGDB
TMEM106B
Tbio
Novelty:  0.01726494
Score:  0.705
Data Source:  STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
Score:  0.682
Data Source:  STRINGDB
MAP1S
Tbio
Novelty:  0.02643414
Score:  0.675
Data Source:  STRINGDB
ASTN2
Tbio
Novelty:  0.05192464
Score:  0.668
Data Source:  STRINGDB
Publication Statistics
PubMed Score  75.62

PubMed score by year
PubTator Score  29.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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