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Tbio
AKR1E2
1,5-anhydro-D-fructose reductase

Protein Summary
Description
Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity towards 9,10-phenanthrenequinone (in vitro) (PubMed:12604216, PubMed:15118078). The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298375
  • ENSP00000298375
  • ENSG00000165568
  • ENST00000334019
  • ENSP00000335034
  • ENST00000345253
  • ENSP00000335603
  • ENST00000463345
  • ENSP00000436794
  • ENST00000532248
  • ENSP00000432947

Symbol
  • AKR1CL2
  • AKRDC1
  • TAKR
  • hTSP
  • htAKR
  • AKRDC1
  • AKR1CL2
  • LoopADR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
cell type or tissue
0.61
protein domain
0.58
tissue sample
0.54
transcription factor perturbation
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
10
11
90.4
BMI-adjusted waist-hip ratio
3
9
10
87.3
body fat distribution
2
1
4
75
hip circumference
1
7
7
74.8
BMI-adjusted waist circumference
1
2
2
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
11
90.4
BMI-adjusted waist-hip ratio
10
87.3
body fat distribution
4
75
hip circumference
7
74.8
BMI-adjusted waist circumference
2
63.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member E2
VGNC:11632
746502
Macaque
aldo-keto reductase family 1 member E2
711035
Mouse
MGI:1914758
56043
Rat
RGD:1309599
307091
Dog
aldo-keto reductase family 1 member E2
VGNC:37769
608809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldo-keto reductase family 1 member E2
Macaque
aldo-keto reductase family 1 member E2
Mouse
Rat
Dog
aldo-keto reductase family 1 member E2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JD6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (7)
1 – 7 of 7
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.758
Data Source:  STRINGDB
ZNF776
Tdark
Family:  TF
Novelty:  7.01411509
Score:  0.544
Data Source:  STRINGDB
MFSD6L
Tdark
Novelty:  1.62242256
Score:  0.51
Data Source:  STRINGDB
WDR87
Tdark
Novelty:  1.27440707
Score:  0.471
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.453
Data Source:  STRINGDB
AKR7A3
Tbio
Family:  Enzyme
Novelty:  0.10681298
Score:  0.445
Data Source:  STRINGDB
RNLS
Tbio
Family:  Enzyme
Novelty:  0.00614589
Score:  0.445
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.12

PubMed score by year
PubTator Score  32.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer