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Tbio
EAF1
ELL-associated factor 1

Protein Summary
Description
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396842
  • ENSP00000380054
  • ENSG00000144597
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
hub protein
0.85
transcription factor binding site profile
0.85
microRNA
0.72
cell type or tissue
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.71   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ELL associated factor 1
VGNC:1799
743603
Macaque
ELL associated factor 1
694057
Mouse
MGI:1921677
74427
Rat
RGD:1310057
306261
Dog
ELL associated factor 1
VGNC:40171
485656
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ELL associated factor 1
Macaque
ELL associated factor 1
Mouse
Rat
Dog
ELL associated factor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JC9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Formation of RNA Pol II elongation complex (R-HSA-112382)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Gene Ontology Terms (11)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (117)
1 – 10 of 117
ELL
Tbio
Family: Enzyme
Novelty: 0.00424352
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
ELL3
Tbio
Family: Enzyme
Novelty: 0.18245631
p_int: 1
Score: 0.74
Data Source: BioPlex,STRINGDB
ELL2
Tbio
Family: Enzyme
Novelty: 0.040736
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Score: 0.97
Data Source: BioPlex,STRINGDB
ICE1
Tbio
Novelty: 0.0208695
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 2e-9
Score: 0.647
Data Source: BioPlex,STRINGDB
ICE2
Tbio
Novelty: 0.03407933
p_int: 0.999999722
p_ni: 2.7e-7
p_wrong: 8e-9
Score: 0.334
Data Source: BioPlex,STRINGDB
EAF2
Tbio
Family: TF
Novelty: 0.08392419
p_int: 0.999999636
p_ni: 9.9e-8
p_wrong: 2.65e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
AFF4
Tbio
Family: TF
Novelty: 0.02113896
p_int: 0.999999622
p_ni: 3.78e-7
Score: 0.979
Data Source: BioPlex,STRINGDB
AFF1
Tbio
Family: TF
Novelty: 0.00094358
p_int: 0.999998756
p_ni: 0.000001244
Score: 0.913
Data Source: BioPlex,STRINGDB
MLLT1
Tbio
Novelty: 0.00328241
p_int: 0.999992404
p_ni: 0.000007581
p_wrong: 1.4e-8
Score: 0.968
Data Source: BioPlex,STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
p_int: 0.999970473
p_ni: 0.000029527
Score: 0.199
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1.71

PubMed score by year
PubTator Score  7.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer