LOXL4
Lysyl oxidase homolog 4
Protein Summary
May modulate the formation of a collagenous extracellular matrix. This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
- ENST00000260702
- ENSP00000260702
- ENSG00000138131
- LOXC
- LOXC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
histone modification site profile | 0.76 | ||
PubMedID | 0.68 | ||
transcription factor | 0.64 | ||
molecular function | 0.6 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.72 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.72 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 52 | |||||
body height | 1 | 1 | 1 | 10 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 52 | |||||
body height | 1 | 10 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lysyl oxidase like 4 | VGNC:4728 | 466175 | |||||
Mouse | MGI:1914823 | 67573 | ||||||
Rat | RGD:1308588 | 309380 | ||||||
Dog | lysyl oxidase like 4 | VGNC:42741 | 486830 | |||||
Horse | lysyl oxidase like 4 | VGNC:19726 | 100070637 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lysyl oxidase like 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysyl oxidase like 4 | |||||
Horse | lysyl oxidase like 4 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (7)
Reactome (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Assembly of collagen fibrils and other multimeric structures | ||||
Reactome | Collagen formation | ||||
Reactome | Crosslinking of collagen fibrils | ||||
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Assembly of collagen fibrils and other multimeric structures | ||||
Collagen formation | ||||
Crosslinking of collagen fibrils | ||||
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Gene Ontology Terms (9)
Functions (3)
Components (4)
Processes (2)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (43)
1 – 10 of 43
SEPHS2
Family: Enzyme
Novelty: 0.01657572
p_int: 0.998673051
p_ni: 0.000066449
p_wrong: 0.001260499
Score: 0.379
Data Source: BioPlex,STRINGDB
CCT6B
Novelty: 0.28933315
p_int: 0.958774341
p_ni: 0.041225659
Score: 0.19
Data Source: BioPlex,STRINGDB
CCT6A
Novelty: 0.02368046
p_int: 0.776968877
p_ni: 0.223031123
Score: 0.177
Data Source: BioPlex,STRINGDB
ELN
Novelty: 0.00026801
Score: 0.956
Data Source: STRINGDB
BMP1
Novelty: 0.00299518
Score: 0.934
Data Source: STRINGDB
FBLN5
Novelty: 0.00599598
Score: 0.928
Data Source: STRINGDB
LOXL1
Family: Enzyme
Novelty: 0.00479897
Score: 0.928
Data Source: STRINGDB
TLL1
Novelty: 0.02261325
Score: 0.925
Data Source: STRINGDB
LOX
Family: Enzyme
Novelty: 0.000273
Score: 0.92
Data Source: STRINGDB
TLL2
Novelty: 0.04888109
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score 41.72
PubMed score by year
PubTator Score 27.5
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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