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Tchem
LOXL4
Lysyl oxidase homolog 4

Protein Summary
Description
May modulate the formation of a collagenous extracellular matrix. This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260702
  • ENSP00000260702
  • ENSG00000138131

Symbol
  • LOXC
  • LOXC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
histone modification site profile
0.76
PubMedID
0.68
transcription factor
0.64
molecular function
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.24   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.24   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (43)
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
p_int:  0.998673051
p_ni:  0.000066449
p_wrong:  0.001260499
Score:  0.379
Data Source:  BioPlex,STRINGDB
CCT6B
Tbio
Novelty:  0.28933315
p_int:  0.958774341
p_ni:  0.041225659
Score:  0.19
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.776968877
p_ni:  0.223031123
Score:  0.177
Data Source:  BioPlex,STRINGDB
ELN
Tbio
Novelty:  0.00026801
Score:  0.956
Data Source:  STRINGDB
BMP1
Tchem
Novelty:  0.00299518
Score:  0.934
Data Source:  STRINGDB
FBLN5
Tbio
Novelty:  0.00599598
Score:  0.928
Data Source:  STRINGDB
LOXL1
Tbio
Family:  Enzyme
Novelty:  0.00479897
Score:  0.928
Data Source:  STRINGDB
TLL1
Tchem
Novelty:  0.02261325
Score:  0.925
Data Source:  STRINGDB
LOX
Tchem
Family:  Enzyme
Novelty:  0.000273
Score:  0.92
Data Source:  STRINGDB
TLL2
Tchem
Novelty:  0.04888109
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen formation
Crosslinking of collagen fibrils
Elastic fibre formation
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
3
3
1.4
97.9
serum metabolite measurement
4
1
1
1.1
94.8
urinary metabolite measurement
1
1
1
88.2
body mass index
1
1
1
68.6
carotid artery intima media thickness
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
1.4
97.9
serum metabolite measurement
1
1.1
94.8
urinary metabolite measurement
1
88.2
body mass index
1
68.6
carotid artery intima media thickness
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 4
VGNC:4728
466175
Mouse
MGI:1914823
67573
Rat
RGD:1308588
309380
Dog
lysyl oxidase like 4
VGNC:42741
486830
Horse
lysyl oxidase like 4
VGNC:19726
100070637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysyl oxidase like 4
Mouse
Rat
Dog
lysyl oxidase like 4
Horse
lysyl oxidase like 4
Publication Statistics
PubMed Score 52.24
PubMed score by year
PubTator Score 27.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title