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Tbio
CDK5RAP3
CDK5 regulatory subunit-associated protein 3

Protein Summary
Description
Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). (Microb ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338399
  • ENSP00000344683
  • ENSG00000108465
  • ENST00000536708
  • ENSP00000438886

Symbol
  • IC53
  • LZAP
  • C53
  • IC53
  • LZAP
  • HSF-27
  • MST016
  • PP1553
  • OK/SW-cl.114
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
histone modification site profile
0.84
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.25   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.25   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3
0
1.1
93.5
BMI-adjusted hip circumference
2
3
4
76.5
hemoglobin measurement
1
1
1
72.9
hematocrit
1
1
1
63.4
heel bone mineral density
2
2
2
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
93.5
BMI-adjusted hip circumference
4
76.5
hemoglobin measurement
1
72.9
hematocrit
1
63.4
heel bone mineral density
2
61.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 3
VGNC:9228
455182
Macaque
CDK5 regulatory subunit associated protein 3
695189
Mouse
MGI:1933126
80280
Rat
RGD:620002
80278
Dog
CDK5 regulatory subunit associated protein 3
VGNC:39059
480541
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 3
Macaque
CDK5 regulatory subunit associated protein 3
Mouse
Rat
Dog
CDK5 regulatory subunit associated protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JB5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.999999999
p_ni:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
UFL1
Tbio
Family:  Enzyme
Novelty:  0.02941148
p_int:  0.999984423
p_ni:  0.000015418
p_wrong:  1.59e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
CD274
Tclin
Novelty:  0.00013449
p_int:  0.99995421
p_ni:  0.00004579
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.996025757
p_ni:  0.003974242
p_wrong:  1e-9
Data Source:  BioPlex
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.994062852
p_ni:  0.005937148
Score:  0.638
Data Source:  BioPlex,STRINGDB
TMED4
Tdark
Novelty:  0.22372593
p_int:  0.992486808
p_ni:  0.007513192
Score:  0.185
Data Source:  BioPlex,STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
p_int:  0.985406912
p_ni:  0.014593088
Data Source:  BioPlex
TMED1
Tbio
Novelty:  0.11862267
p_int:  0.963967459
p_ni:  0.036032541
Score:  0.21
Data Source:  BioPlex,STRINGDB
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.962997516
p_ni:  0.037002484
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.958598855
p_ni:  0.041398648
p_wrong:  0.000002496
Data Source:  BioPlex
Publication Statistics
PubMed Score  37.25

PubMed score by year
PubTator Score  44.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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