You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DNAH8
Dynein heavy chain 8, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359357
  • ENSP00000352312
  • ENSG00000124721

Symbol
  • hdhc9
  • ATPase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
cellular component
0.76
tissue
0.71
cell line
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
0
1.1
20.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
0
1.1
20.8
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (110)
1 – 10 of 110
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.941
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.938
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.936
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.935
Data Source: STRINGDB
DYNLT3
Tbio
Novelty: 0.10969629
Score: 0.934
Data Source: STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.934
Data Source: STRINGDB
DNAH17
Tdark
Novelty: 0.14878692
Score: 0.922
Data Source: STRINGDB
DNAH3
Tdark
Novelty: 0.0628368
Score: 0.918
Data Source: STRINGDB
DNAH7
Tbio
Novelty: 0.13519686
Score: 0.917
Data Source: STRINGDB
DNAH6
Tdark
Novelty: 0.18343511
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.84

PubMed score by year
PubTator Score  4154.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer