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Tdark
MS4A14
Membrane-spanning 4-domains subfamily A member 14

Protein Classes
Protein Summary
Description
May be involved in signal transduction as a component of a multimeric receptor complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300187
  • ENSP00000300187
  • ENSG00000166928
  • ENST00000395005
  • ENSP00000378453
  • ENST00000531783
  • ENSP00000433761

Symbol
  • MS4A13
  • MS4A16
  • MS4A16
  • NYD-SP21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
cell line
0.58
phenotype
0.58
disease
0.54
PubMedID
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.94   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
79.2
monocyte percentage of leukocytes
1
1
1
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
79.2
monocyte percentage of leukocytes
1
35.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A14
VGNC:12613
736639
Dog
membrane spanning 4-domains A14
VGNC:43431
476901
Horse
membrane spanning 4-domains A14
VGNC:51993
100061472
Cow
membrane spanning 4-domains A14
VGNC:31683
767816
Pig
membrane spanning 4-domains A14
100620949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A14
Dog
membrane spanning 4-domains A14
Horse
membrane spanning 4-domains A14
Cow
membrane spanning 4-domains A14
Pig
membrane spanning 4-domains A14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96JA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (42)
1 – 10 of 42
MS4A6A
Tbio
Novelty: 0.04742307
Score: 0.84
Data Source: STRINGDB
TMEM176A
Tbio
Novelty: 0.11044555
Score: 0.807
Data Source: STRINGDB
MS4A18
Tdark
Novelty: 5.50403226
Score: 0.762
Data Source: STRINGDB
MS4A6E
Tdark
Novelty: 0.29944161
Score: 0.693
Data Source: STRINGDB
MS4A7
Tdark
Novelty: 1.1093531
Score: 0.654
Data Source: STRINGDB
ASNSD1
Tdark
Family: Enzyme
Novelty: 0.54006324
Score: 0.634
Data Source: STRINGDB
ASDURF
Tdark
Novelty: 0.54006324
Score: 0.634
Data Source: STRINGDB
LHFPL6
Tbio
Novelty: 0.11121552
Score: 0.588
Data Source: STRINGDB
TMEM176B
Tbio
Novelty: 0.02452255
Score: 0.58
Data Source: STRINGDB
C7orf61
Tdark
Novelty: 3.9028559
Score: 0.575
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.94

PubMed score by year
PubTator Score  0.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer