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Tbio
CELF6
CUGBP Elav-like family member 6

Protein Summary
Description
RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA. Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287202
  • ENSP00000287202
  • ENSG00000140488
  • ENST00000395258
  • ENSP00000378677
  • ENST00000543764
  • ENSP00000439956
  • ENST00000567083
  • ENSP00000457863

Symbol
  • BRUNOL6
  • BRUNOL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.77
histone modification site profile
0.75
cell type or tissue
0.62
trait
0.61
virus perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
1
1
0
5.9
30.2
serum alanine aminotransferase measurement
1
1
0
5.5
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aspartate aminotransferase measurement
0
5.9
30.2
serum alanine aminotransferase measurement
0
5.5
1.5
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923433
76183
Cow
CUGBP Elav-like family member 6
539205
Pig
CUGBP Elav-like family member 6
100511645
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
CUGBP Elav-like family member 6
Pig
CUGBP Elav-like family member 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96J87-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (28)
1 – 10 of 28
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
Score:  0.743
Data Source:  STRINGDB
RRM1
Tclin
Family:  Enzyme
Novelty:  0.00083196
Score:  0.712
Data Source:  STRINGDB
CEBPD
Tbio
Family:  TF
Novelty:  0.00121121
Score:  0.616
Data Source:  STRINGDB
PARP6
Tchem
Family:  Enzyme
Novelty:  0.10074447
Score:  0.57
Data Source:  STRINGDB
WDR83
Tbio
Novelty:  0.11602568
Score:  0.558
Data Source:  STRINGDB
ERI2
Tbio
Family:  Enzyme
Novelty:  0.10111379
Score:  0.554
Data Source:  STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
Score:  0.538
Data Source:  STRINGDB
RBM6
Tbio
Novelty:  0.06349982
Score:  0.535
Data Source:  STRINGDB
TNNT2
Tbio
Novelty:  0.00044568
Score:  0.527
Data Source:  STRINGDB
ERI1
Tbio
Family:  Enzyme
Novelty:  0.00959105
Score:  0.509
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.98

PubMed score by year
PubTator Score  2.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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