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Tbio
KIRREL1
Kin of IRRE-like protein 1

Protein Summary
Description
Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359209
  • ENSP00000352138
  • ENSG00000183853

Symbol
  • KIRREL
  • NEPH1
  • NEPH1
  • KIRREL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.16   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.16   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
6.2
75
age at onset
1
1
0
6.2
38.2
Myopia
1
1
0
6.2
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
6.2
75
age at onset
0
6.2
38.2
Myopia
0
6.2
38.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kirre like nephrin family adhesion molecule 1
VGNC:14866
469523
Macaque
kirre like nephrin family adhesion molecule 1
718870
Mouse
MGI:1891396
170643
Rat
RGD:727883
310695
Dog
kirre like nephrin family adhesion molecule 1
VGNC:42418
488606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kirre like nephrin family adhesion molecule 1
Macaque
kirre like nephrin family adhesion molecule 1
Mouse
Rat
Dog
kirre like nephrin family adhesion molecule 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96J84-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Nephrin/Neph1 signaling in the kidney podocyte
PathwayCommons: netpath
EGFR1
PathwayCommons: netpath
TCR
Name
Explore in Pharos
Explore in Source
Nephrin/Neph1 signaling in the kidney podocyte
EGFR1
TCR
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (105)
1 – 10 of 105
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999413961
p_ni:  0.000586039
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.99875972
p_ni:  0.00124028
p_wrong:  1e-9
Data Source:  BioPlex
CCKBR
Tclin
Family:  GPCR
Novelty:  0.00158159
p_int:  0.998323948
p_ni:  0.001676052
Score:  0.158
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.997585949
p_ni:  0.002414051
p_wrong:  1e-9
Data Source:  BioPlex
UBR3
Tbio
Family:  Enzyme
Novelty:  0.14930754
p_int:  0.995869281
p_ni:  0.004130719
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.991389062
p_ni:  0.008610938
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.978988492
p_ni:  0.0210115
p_wrong:  8e-9
Data Source:  BioPlex
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.972192992
p_ni:  0.027807008
Data Source:  BioPlex
CPA5
Tbio
Family:  Enzyme
Novelty:  0.0516555
p_int:  0.958308755
p_ni:  0.041691245
Data Source:  BioPlex
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.954317962
p_ni:  0.045681013
p_wrong:  0.000001025
Data Source:  BioPlex
Publication Statistics
PubMed Score  27.16

PubMed score by year
PubTator Score  17.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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