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Tdark
TPD52L3
Tumor protein D55

Protein Summary
Description
This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314556
  • ENSP00000318665
  • ENSG00000170777
  • ENST00000344545
  • ENSP00000341677
  • ENST00000381428
  • ENSP00000370836

Symbol
  • D55
  • hD55
  • NYDSP25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
gene perturbation
0.65
cell line
0.54
microRNA
0.54
tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.98   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
74.2
hematocrit
2
2
2
72.9
2
2
0
1.2
31.2
1
1
0
1.1
2.9
eosinophil percentage of leukocytes
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
74.2
hematocrit
2
72.9
0
1.2
31.2
0
1.1
2.9
eosinophil percentage of leukocytes
1
1.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tumor protein D52 like 3 [Source:HGNC Symbol;Acc:HGNC:23382]
Mouse
MGI:1913995
66745
Rat
RGD:1309391
293894
Dog
tumor protein D52 like 3
481533
Horse
tumor protein D52 like 3 [Source:HGNC Symbol;Acc:HGNC:23382]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tumor protein D52 like 3 [Source:HGNC Symbol;Acc:HGNC:23382]
Mouse
Rat
Dog
tumor protein D52 like 3
Horse
tumor protein D52 like 3 [Source:HGNC Symbol;Acc:HGNC:23382]
Protein-Protein Interactions (13)
1 – 10 of 13
PDIK1L
Tdark
Family: Kinase
Novelty: 0.4630487
Score: 0.574
Data Source: STRINGDB
TEX33
Tdark
Novelty: 0.48097809
Score: 0.551
Data Source: STRINGDB
MEMO1
Tbio
Novelty: 0.0506558
Score: 0.547
Data Source: STRINGDB
MTMR2
Tbio
Family: Enzyme
Novelty: 0.01403122
Score: 0.531
Data Source: STRINGDB
GLRA1
Tclin
Family: IC
Novelty: 0.00565137
Score: 0.523
Data Source: STRINGDB
IFT74
Tbio
Novelty: 0.07195266
Score: 0.511
Data Source: STRINGDB
NIM1K
Tchem
Family: Kinase
Novelty: 0.03931684
Score: 0.475
Data Source: STRINGDB
PAFAH1B2
Tchem
Family: Enzyme
Novelty: 0.07918203
Score: 0.472
Data Source: STRINGDB
ADAMTS6
Tbio
Family: Enzyme
Novelty: 0.08054942
Score: 0.471
Data Source: STRINGDB
WDR47
Tdark
Novelty: 0.51632776
Score: 0.44
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.98

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer