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Tbio
ABCC11
ATP-binding cassette sub-family C member 11

Protein Summary
Description
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689). The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353782
  • ENSP00000311326
  • ENSG00000121270
  • ENST00000356608
  • ENSP00000349017
  • ENST00000394747
  • ENSP00000378230
  • ENST00000394748
  • ENSP00000378231

Symbol
  • MRP8
  • WW
  • EWWD
  • MRP8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.85
tissue
0.64
tissue sample
0.62
cell line
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.18   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.18   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hyperhidrosis
1
1
0
1.6
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Hyperhidrosis
0
1.6
37.6
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 11
VGNC:13650
473275
Macaque
ATP binding cassette subfamily C member 11
716552
Dog
ATP binding cassette subfamily C member 11
VGNC:37438
100856571
Horse
ATP binding cassette subfamily C member 11
VGNC:14915
100057458
Cow
ATP binding cassette subfamily C member 11
VGNC:25470
101909228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 11
Macaque
ATP binding cassette subfamily C member 11
Dog
ATP binding cassette subfamily C member 11
Horse
ATP binding cassette subfamily C member 11
Cow
ATP binding cassette subfamily C member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96J66-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Transport of small molecules
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
ABCG4
Tbio
Family:  Transporter
Novelty:  0.02628545
Score:  0.918
Data Source:  STRINGDB
PRRT2
Tbio
Novelty:  0.00442931
Score:  0.713
Data Source:  STRINGDB
LIPK
Tbio
Family:  Enzyme
Novelty:  0.11313187
Score:  0.62
Data Source:  STRINGDB
ACSM3
Tbio
Family:  Enzyme
Novelty:  0.02440917
Score:  0.605
Data Source:  STRINGDB
ABCF2
Tbio
Family:  Transporter
Novelty:  0.06782708
Score:  0.603
Data Source:  STRINGDB
GLYATL2
Tbio
Family:  Enzyme
Novelty:  0.28659241
Score:  0.602
Data Source:  STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
Score:  0.568
Data Source:  STRINGDB
CMBL
Tbio
Family:  Enzyme
Novelty:  0.00579339
Score:  0.529
Data Source:  STRINGDB
FSIP2
Tdark
Novelty:  0.16245939
Score:  0.529
Data Source:  STRINGDB
TMED2
Tbio
Novelty:  0.03731104
Score:  0.516
Data Source:  STRINGDB
Publication Statistics
PubMed Score  81.18

PubMed score by year
PubTator Score  90.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer