ABCC12
Multidrug resistance-associated protein 9
Protein Summary
Probable transporter. This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
- ENST00000311303
- ENSP00000311030
- ENSG00000140798
- ENST00000497206
- ENSP00000431232
- ENST00000529084
- ENSP00000434510
- ENST00000529504
- ENSP00000433333
- ENST00000532494
- ENSP00000437047
- ENST00000534418
- ENSP00000431354
- MRP9
- MRP9
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
protein domain | 0.85 | ||
PubMedID | 0.75 | ||
cell line | 0.59 | ||
transcription factor | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.22 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 197 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.22 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 197 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0