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Tbio
ITCH
E3 ubiquitin-protein ligase Itchy homolog

Protein Summary
Description
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:14602072, PubMed:17028573, PubMed:16387660, PubMed:18718448, PubMed:18718449, PubMed:11046148, PubMed:19592251, PubMed:19116316, PubMed:19881509, PubMed:20491914, PubMed:20392206, PubMed:20068034, PubMed:23146885, PubMed:24790097, PubMed:25631046). Catalyzes 'Lys-29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (PubMed:17028573, PubMed:18718448, PubMed:19131965, PubMed:19881509). Involved in the control of inflammatory signaling pathways (PubMed:19131965). Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (PubMed:19131965). Promotes the association of the complex after TNF stimulation (PubMed:19131965). Once the complex is formed, TNFAIP3 deubiquitinates 'L ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262650
  • ENSP00000262650
  • ENSG00000078747
  • ENST00000374864
  • ENSP00000363998
  • ENST00000535650
  • ENSP00000445608

Symbol
  • AIF4
  • AIP4
  • ADMFD
  • NAPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.96
kinase perturbation
0.84
kinase
0.77
disease perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.14   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.14   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (467)
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.999633178
p_ni:  0.000366822
Score:  0.192
Data Source:  BioPlex,STRINGDB
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.995788269
p_ni:  0.004211731
Score:  0.741
Data Source:  BioPlex,STRINGDB
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.989358607
p_ni:  0.010641393
Data Source:  BioPlex
SPART
Tbio
Novelty:  0.01524727
p_int:  0.987605414
p_ni:  0.012394586
Score:  0.706
Data Source:  BioPlex,STRINGDB
LDLRAD4
Tbio
Novelty:  0.04881486
p_int:  0.986764803
p_ni:  0.013235197
Score:  0.22
Data Source:  BioPlex,STRINGDB
TMEM255A
Tdark
Novelty:  1.03700118
p_int:  0.98374744
p_ni:  0.01625256
Score:  0.163
Data Source:  BioPlex,STRINGDB
ARRDC3
Tbio
Novelty:  0.04840692
p_int:  0.974832371
p_ni:  0.025167629
Score:  0.704
Data Source:  BioPlex,STRINGDB
SARAF
Tbio
Novelty:  0.0383833
p_int:  0.964623191
p_ni:  0.035376809
Data Source:  BioPlex
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.96455227
p_ni:  0.03544773
Data Source:  BioPlex
SMAD7
Tbio
Family:  TF
Novelty:  0.00116343
p_int:  0.961489627
p_ni:  0.038510373
Score:  0.803
Data Source:  BioPlex,STRINGDB
Pathways (51)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

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Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
7
12
97.8
glomerular filtration rate
4
4
4
95.6
sex hormone-binding globulin measurement
6
3
6
90.5
hair color
1
1
0
1.5
85.8
creatinine measurement
2
2
2
83.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
12
97.8
glomerular filtration rate
4
95.6
sex hormone-binding globulin measurement
6
90.5
hair color
0
1.5
85.8
creatinine measurement
2
83.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
itchy E3 ubiquitin protein ligase
VGNC:6170
458191
Macaque
itchy E3 ubiquitin protein ligase
707640
Mouse
MGI:1202301
16396
Rat
RGD:1359556
311567
Dog
itchy E3 ubiquitin protein ligase
VGNC:42117
477199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
itchy E3 ubiquitin protein ligase
Macaque
itchy E3 ubiquitin protein ligase
Mouse
Rat
Dog
itchy E3 ubiquitin protein ligase
Publication Statistics
PubMed Score 164.14
PubMed score by year
PubTator Score 652.47
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title