ITCH
E3 ubiquitin-protein ligase Itchy homolog
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
hub protein | 0.96 | ||
kinase perturbation | 0.84 | ||
kinase | 0.77 | ||
disease perturbation | 0.74 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
DDX58/IFIH1-mediated induction of interferon-alpha/beta | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 7 | 12 | 97.8 | |||||
glomerular filtration rate | 4 | 4 | 4 | 95.6 | |||||
sex hormone-binding globulin measurement | 6 | 3 | 6 | 90.5 | |||||
hair color | 1 | 1 | 0 | 1.5 | 85.8 | ||||
creatinine measurement | 2 | 2 | 2 | 83.2 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
appendicular lean mass | 12 | 97.8 | |||||
glomerular filtration rate | 4 | 95.6 | |||||
sex hormone-binding globulin measurement | 6 | 90.5 | |||||
hair color | 0 | 1.5 | 85.8 | ||||
creatinine measurement | 2 | 83.2 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | itchy E3 ubiquitin protein ligase | VGNC:6170 | 458191 | |||||
Macaque | itchy E3 ubiquitin protein ligase | 707640 | ||||||
Mouse | MGI:1202301 | 16396 | ||||||
Rat | RGD:1359556 | 311567 | ||||||
Dog | itchy E3 ubiquitin protein ligase | VGNC:42117 | 477199 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | itchy E3 ubiquitin protein ligase | |||||
Macaque | itchy E3 ubiquitin protein ligase | |||||
Mouse | ||||||
Rat | ||||||
Dog | itchy E3 ubiquitin protein ligase | |||||
PMID | Year | Title |
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