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Tbio
ADTRP
Androgen-dependent TFPI-regulating protein

Protein Summary
Description
Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229583
  • ENSP00000229583
  • ENSG00000111863
  • ENST00000414691
  • ENSP00000404416

Symbol
  • C6orf105
  • AIG1L
  • C6orf105
  • dJ413H6.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.84
small molecule perturbation
0.69
transcription factor perturbation
0.61
transcription factor
0.57
disease
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.69   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.69   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TTC32
Tdark
Novelty:  0.90327428
Score:  0.808
Data Source:  STRINGDB
DHRS12
Tdark
Family:  Enzyme
Novelty:  0.38384976
Score:  0.665
Data Source:  STRINGDB
SERPINA10
Tbio
Family:  Enzyme
Novelty:  0.01229147
Score:  0.598
Data Source:  STRINGDB
CCDC155
Tbio
Novelty:  0.16516035
Score:  0.575
Data Source:  STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
Score:  0.562
Data Source:  STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
Score:  0.538
Data Source:  STRINGDB
GUCY1A1
Tclin
Family:  Enzyme
Novelty:  0.02289791
Score:  0.531
Data Source:  STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
Score:  0.531
Data Source:  STRINGDB
MIA3
Tbio
Novelty:  0.02784348
Score:  0.53
Data Source:  STRINGDB
TFPI
Tchem
Novelty:  0.00060355
Score:  0.53
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
71.2
insulin measurement
1
1
1
66.3
wellbeing measurement
5
4
5
66.3
lymphocyte count
1
1
1
53.3
neuroticism measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
71.2
insulin measurement
1
66.3
wellbeing measurement
5
66.3
lymphocyte count
1
53.3
neuroticism measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
androgen dependent TFPI regulating protein
VGNC:8157
462435
Macaque
androgen dependent TFPI regulating protein
699609
Mouse
MGI:1924596
109254
Rat
RGD:1305679
361228
Dog
androgen dependent TFPI regulating protein
VGNC:37680
478722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
androgen dependent TFPI regulating protein
Macaque
androgen dependent TFPI regulating protein
Mouse
Rat
Dog
androgen dependent TFPI regulating protein
Publication Statistics
PubMed Score 19.69
PubMed score by year
PubTator Score 7.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title