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Tchem
CPB2
Carboxypeptidase B2

Protein Summary
Description
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000181383
  • ENSP00000181383
  • ENSG00000080618
  • ENST00000645658
  • ENSP00000496703

Symbol
  • CPU
  • PCPB
  • TAFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
biological term
0.94
biological process
0.83
disease
0.64
disease perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 708.24   (req: < 5)
Gene RIFs: 180   (req: <= 3)
Antibodies: 559   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 708.24   (req: >= 5)
Gene RIFs: 180   (req: > 3)
Antibodies: 559   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 153
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carboxypeptidase B2 measurement
1
1
1
73.7
thrombin activatable fibrinolysis inhibitor activation peptide measurement
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carboxypeptidase B2 measurement
1
73.7
thrombin activatable fibrinolysis inhibitor activation peptide measurement
1
67.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase B2
VGNC:14508
452582
Macaque
carboxypeptidase B2
703317
Mouse
MGI:1891837
56373
Rat
RGD:71035
113936
Dog
carboxypeptidase B2
VGNC:39550
608910
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carboxypeptidase B2
Macaque
carboxypeptidase B2
Mouse
Rat
Dog
carboxypeptidase B2
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96IY4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (153)
1 – 10 of 153
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.992
Data Source: STRINGDB
C5
Tclin
Novelty: 0.00225386
Score: 0.966
Data Source: Reactome,STRINGDB
C3
Tbio
Novelty: 0.00019115
Score: 0.941
Data Source: Reactome,STRINGDB
F2R
Tclin
Family: GPCR
Novelty: 0.00080964
Score: 0.94
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.932
Data Source: STRINGDB
AGT
Tbio
Novelty: 0.00049613
Score: 0.931
Data Source: STRINGDB
SERPINC1
Tclin
Novelty: 0.00008721
Score: 0.929
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.916
Data Source: STRINGDB
UBE2A
Tbio
Novelty: 0.01670792
Score: 0.901
Data Source: STRINGDB
F7
Tchem
Family: Enzyme
Novelty: 0.0002521
Score: 0.875
Data Source: STRINGDB
Publication Statistics
PubMed Score  708.24

PubMed score by year
PubTator Score  586.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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