Tchem CPB2 Carboxypeptidase B2

Protein Summary

Description

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• Q96IY4
• A8K464
• Q15114
• Q5T9K1
• Q5T9K2
• Q9P2Y6

Gene Name

• CPB2

Ensembl ID

• ENST00000181383
• ENSP00000181383
• ENSG00000080618
• ENST00000645658
• ENSP00000496703

Symbol

• CPU
• PCPB
• TAFI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
biological term	0.94
biological process	0.83
disease	0.64
disease perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / Carboxypeptidase B2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Carboxypeptidase B2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.67   (req: < 5)

Gene RIFs: 191   (req: <= 3)

Antibodies: 559   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.67   (req: >= 5)

Gene RIFs: 191   (req: > 3)

Antibodies: 559   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 186

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0