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Tbio
NSL1
Kinetochore-associated protein NSL1 homolog

Protein Summary
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366977
  • ENSP00000355944
  • ENSG00000117697
  • ENST00000626725
  • ENSP00000486783

Symbol
  • C1orf48
  • DC8
  • MIS14
  • C1orf48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.89
kinase perturbation
0.84
cellular component
0.65
microRNA
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
81.4
hematocrit
2
2
2
74
reticulocyte count
1
1
1
44.2
childhood onset asthma
1
1
0
1.1
40.7
reticulocyte measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
81.4
hematocrit
2
74
reticulocyte count
1
44.2
childhood onset asthma
0
1.1
40.7
reticulocyte measurement
1
29
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NSL1, MIS12 kinetochore complex component
VGNC:8083
457722
Macaque
NSL1, MIS12 kinetochore complex component
710371
Mouse
MGI:2685830
381318
Rat
RGD:1562052
498310
Dog
NSL1, MIS12 kinetochore complex component
VGNC:43986
480025
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NSL1, MIS12 kinetochore complex component
Macaque
NSL1, MIS12 kinetochore complex component
Mouse
Rat
Dog
NSL1, MIS12 kinetochore complex component
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96IY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (145)
1 – 10 of 145
DSN1
Tbio
Novelty:  0.05336903
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SPC24
Tbio
Novelty:  0.03166479
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  1
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty:  0.05319446
p_int:  1
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
ZWINT
Tbio
Novelty:  0.02153276
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MIS12
Tbio
Novelty:  0.05345698
p_int:  0.999999644
p_ni:  3.54e-7
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.99999041
p_ni:  0.00000959
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.999983009
p_ni:  0.000016991
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty:  0.01069726
p_int:  0.999962695
p_ni:  0.000037305
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999564195
p_ni:  0.000434924
p_wrong:  8.8e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  71.08

PubMed score by year
PubTator Score  25.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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