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Tdark
SEC22A
Vesicle-trafficking protein SEC22a

Protein Summary
Description
May be involved in vesicle transport between the ER and the Golgi complex. The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309934
  • ENSP00000310521
  • ENSG00000121542
  • ENST00000492595
  • ENSP00000417972

Symbol
  • SEC22L2
  • SEC22L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cell type or tissue
0.86
kinase perturbation
0.76
tissue sample
0.71
transcription factor perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC22 homolog A, vesicle trafficking protein
VGNC:2559
460638
Macaque
SEC22 homolog A, vesicle trafficking protein
715277
Mouse
MGI:2447876
317717
Rat
RGD:621659
117513
Dog
SEC22 homolog A, vesicle trafficking protein
VGNC:45967
100686076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC22 homolog A, vesicle trafficking protein
Macaque
SEC22 homolog A, vesicle trafficking protein
Mouse
Rat
Dog
SEC22 homolog A, vesicle trafficking protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96IW7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (154)
1 – 10 of 154
MIF
Tchem
Novelty: 0.00056843
p_int: 0.937908145
p_ni: 0.000141524
p_wrong: 0.061950331
Data Source: BioPlex
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.913726814
p_ni: 0.000008973
p_wrong: 0.086264213
Data Source: BioPlex
GOSR2
Tbio
Novelty: 0.02447711
Score: 0.996
Data Source: STRINGDB
STX5
Tbio
Novelty: 0.00964918
Score: 0.994
Data Source: STRINGDB
BET1
Tdark
Novelty: 0.01791164
Score: 0.992
Data Source: STRINGDB
YKT6
Tbio
Novelty: 0.01591063
Score: 0.984
Data Source: STRINGDB
USO1
Tbio
Novelty: 0.02066669
Score: 0.984
Data Source: STRINGDB
SCFD1
Tbio
Novelty: 0.02924747
Score: 0.982
Data Source: STRINGDB
SEC23A
Tbio
Novelty: 0.0384262
Score: 0.975
Data Source: STRINGDB
STX17
Tbio
Novelty: 0.01788363
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.98

PubMed score by year
PubTator Score  0.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer