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Tbio
NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

Protein Classes
Protein Summary
Description
Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding di ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280700
  • ENSP00000280700
  • ENSG00000151092
  • ENST00000396649
  • ENSP00000379886
  • ENST00000417874
  • ENSP00000389888
  • ENST00000428257
  • ENSP00000387430

Symbol
  • PNG1
  • CDDG
  • PNG1
  • CDG1V
  • PNGase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.87
disease perturbation
0.74
protein domain
0.73
transcription factor binding site profile
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.01   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.01   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein modification
Protein-Protein Interactions (79)
1 – 10 of 79
NAGPA
Tbio
Family: Enzyme
Novelty: 0.03136768
p_int: 0.994181736
p_ni: 0.005818264
Score: 0.221
Data Source: BioPlex,STRINGDB
B4GALT4
Tbio
Family: Enzyme
Novelty: 0.11226614
p_int: 0.988384015
p_ni: 0.011615985
Score: 0.532
Data Source: BioPlex,STRINGDB
SGSH
Tbio
Family: Enzyme
Novelty: 0.00670111
p_int: 0.959269562
p_ni: 0.040730438
Data Source: BioPlex
AMIGO1
Tbio
Novelty: 0.00864791
p_int: 0.908291088
p_ni: 0.091708912
Data Source: BioPlex
TMEM25
Tdark
Novelty: 0.35505784
p_int: 0.875747945
p_ni: 0.124252055
Data Source: BioPlex
LINGO1
Tbio
Novelty: 0.00778085
p_int: 0.851028242
p_ni: 0.148971758
Score: 0.187
Data Source: BioPlex,STRINGDB
RAD23B
Tbio
Novelty: 0.00672104
p_int: 0.850811284
p_ni: 0.149188716
Score: 0.993
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
Score: 0.976
Data Source: STRINGDB
AMFR
Tbio
Family: Enzyme
Novelty: 0.00533547
Score: 0.966
Data Source: STRINGDB
DERL1
Tbio
Novelty: 0.01382722
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.01

PubMed score by year
PubTator Score  180.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer