ZNF496
Zinc finger protein 496
Protein Summary
DNA-binding transcription factor that can both act as an activator and a repressor.
- ENST00000294753
- ENSP00000294753
- ENSG00000162714
- ZKSCAN17
- NIZP1
- ZFP496
- ZSCAN49
- ZKSCAN17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
kinase perturbation | 0.81 | ||
histone modification site profile | 0.73 | ||
transcription factor binding site profile | 0.72 | ||
cell line | 0.64 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.68 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.68 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
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Protein-Protein Interactions (36)
1 – 10 of 36
ZNF232
Family: TF
Novelty: 0.68288358
p_int: 0.999802742
p_ni: 0.000197206
p_wrong: 5.2e-8
Data Source: BioPlex
ZNF397
Family: TF
Novelty: 0.60034816
p_int: 0.999784389
p_ni: 0.000215329
p_wrong: 2.81e-7
Data Source: BioPlex
GTF3C2
Novelty: 0.1827844
p_int: 0.999580813
p_ni: 0.000418856
p_wrong: 3.32e-7
Score: 0.557
Data Source: BioPlex,STRINGDB
XAGE1A
Novelty: 0.04421526
p_int: 0.99926839
p_ni: 0.00073159
p_wrong: 2e-8
Data Source: BioPlex
CSNK2B
Family: Kinase
Novelty: 0.00152367
p_int: 0.99918176
p_ni: 0.000811162
p_wrong: 0.000007078
Data Source: BioPlex
PRM2
Novelty: 0.0050028
p_int: 0.998485819
p_ni: 0.001508205
p_wrong: 0.000005976
Data Source: BioPlex
PPAN
Novelty: 0.01063709
p_int: 0.998425197
p_ni: 0.001571226
p_wrong: 0.000003576
Data Source: BioPlex
ZSCAN1
Family: TF
Novelty: 0.0217244
p_int: 0.998255863
p_ni: 0.000255809
p_wrong: 0.001488328
Score: 0.205
Data Source: BioPlex,STRINGDB
FOXD4L6
Family: TF
Novelty: 9.78461538
p_int: 0.997770203
p_ni: 0.00222691
p_wrong: 0.000002887
Score: 0.234
Data Source: BioPlex,STRINGDB
FBL
Family: Enzyme
Novelty: 0.00080634
p_int: 0.997685449
p_ni: 0.000169345
p_wrong: 0.002145206
Score: 0.51
Data Source: BioPlex,STRINGDB
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Gene Ontology Terms (5)
Functions (3)
Components (1)
Processes (1)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 2 | 3 | 3 | 88.5 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 72.7 | |||||
leukocyte count | 1 | 1 | 1 | 53.3 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 48.5 | |||||
neutrophil count | 1 | 1 | 1 | 12.8 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 3 | 88.5 | |||||
monocyte percentage of leukocytes | 2 | 72.7 | |||||
leukocyte count | 1 | 53.3 | |||||
serum non-albumin protein measurement | 1 | 48.5 | |||||
neutrophil count | 1 | 12.8 | |||||
Find similar targets by:
UniProt Keyword
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|---|---|---|---|
GWAS Trait
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Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | zinc finger protein 496 | VGNC:8138 | 739211 | |||||
Macaque | zinc finger protein 496 | 709694 | ||||||
Mouse | MGI:2679270 | 268417 | ||||||
Rat | RGD:1304611 | 287361 | ||||||
Dog | zinc finger protein 496 | VGNC:48740 | 490575 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | zinc finger protein 496 | |||||
Macaque | zinc finger protein 496 | |||||
Mouse | ||||||
Rat | ||||||
Dog | zinc finger protein 496 | |||||
Publication Statistics
PubMed Score 5.68
PubMed score by year
PubTator Score 4.50
PubTator score by year