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Tbio
ZNF496
Zinc finger protein 496

Protein Summary
Description
DNA-binding transcription factor that can both act as an activator and a repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294753
  • ENSP00000294753
  • ENSG00000162714

Symbol
  • ZKSCAN17
  • NIZP1
  • ZFP496
  • ZSCAN49
  • ZKSCAN17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.81
histone modification site profile
0.73
transcription factor binding site profile
0.72
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.68   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.68   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (36)
1 – 10 of 36
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.999802742
p_ni:  0.000197206
p_wrong:  5.2e-8
Data Source:  BioPlex
ZNF397
Tbio
Family:  TF
Novelty:  0.60034816
p_int:  0.999784389
p_ni:  0.000215329
p_wrong:  2.81e-7
Data Source:  BioPlex
GTF3C2
Tdark
Novelty:  0.1827844
p_int:  0.999580813
p_ni:  0.000418856
p_wrong:  3.32e-7
Score:  0.557
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.99926839
p_ni:  0.00073159
p_wrong:  2e-8
Data Source:  BioPlex
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.99918176
p_ni:  0.000811162
p_wrong:  0.000007078
Data Source:  BioPlex
PRM2
Tbio
Novelty:  0.0050028
p_int:  0.998485819
p_ni:  0.001508205
p_wrong:  0.000005976
Data Source:  BioPlex
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.998425197
p_ni:  0.001571226
p_wrong:  0.000003576
Data Source:  BioPlex
ZSCAN1
Tbio
Family:  TF
Novelty:  0.0217244
p_int:  0.998255863
p_ni:  0.000255809
p_wrong:  0.001488328
Score:  0.205
Data Source:  BioPlex,STRINGDB
FOXD4L6
Tdark
Family:  TF
Novelty:  9.78461538
p_int:  0.997770203
p_ni:  0.00222691
p_wrong:  0.000002887
Score:  0.234
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.997685449
p_ni:  0.000169345
p_wrong:  0.002145206
Score:  0.51
Data Source:  BioPlex,STRINGDB
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
3
3
88.5
monocyte percentage of leukocytes
2
2
2
72.7
leukocyte count
1
1
1
53.3
serum non-albumin protein measurement
1
1
1
48.5
neutrophil count
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
88.5
monocyte percentage of leukocytes
2
72.7
leukocyte count
1
53.3
serum non-albumin protein measurement
1
48.5
neutrophil count
1
12.8
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 496
VGNC:8138
739211
Macaque
zinc finger protein 496
709694
Mouse
MGI:2679270
268417
Rat
RGD:1304611
287361
Dog
zinc finger protein 496
VGNC:48740
490575
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 496
Macaque
zinc finger protein 496
Mouse
Rat
Dog
zinc finger protein 496
Publication Statistics
PubMed Score 5.68
PubMed score by year
PubTator Score 4.50
PubTator score by year