Tbio TENT5A Terminal nucleotidyltransferase 5A

Protein Summary

Description

Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.

Uniprot Accession IDs

• Q96IP4
• A8K7U4
• Q5TF86
• Q8NFZ9
• Q9BW32
• Q9NXV5

Gene Name

• TENT5A

Ensembl ID

• ENST00000320172
• ENSP00000318298
• ENSG00000112773
• ENST00000369754
• ENSP00000358769

Symbol

• C6orf37
• FAM46A
• XTP11
• OI18
• XTP11
• FAM46A
• C6orf37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
microRNA	0.83
transcription factor binding site profile	0.81
gene perturbation	0.76
histone modification site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (77)

Explore Interacting Targets

1 – 10 of 77

• See Interactions on String-DB

FNDC3B

Tbio

Novelty:  0.03060075

p_int:  1

Score:  0.687

Data Source:  BioPlex,STRINGDB

FNDC3A

Tbio

Novelty:  0.04721453

p_int:  0.999999932

p_ni:  6.2e-8

p_wrong:  5e-9

Score:  0.157

Data Source:  BioPlex,STRINGDB

BCCIP

Tbio

Novelty:  0.02710491

p_int:  0.999913045

p_ni:  0.000086955

Score:  0.557

Data Source:  BioPlex,STRINGDB

DCAF6

Tbio

Novelty:  0.01269552

p_int:  0.999165367

p_ni:  0.000834633

Score:  0.479

Data Source:  BioPlex,STRINGDB

DDX11

Tbio

Family:  Enzyme

Novelty:  0.02282234

p_int:  0.998985883

p_ni:  0.001014116

p_wrong:  1e-9

Score:  0.299

Data Source:  BioPlex,STRINGDB

HDLBP

Tbio

Novelty:  0.00979636

p_int:  0.998461901

p_ni:  0.001538099

Score:  0.375

Data Source:  BioPlex,STRINGDB

EIF4G3

Tbio

Novelty:  0.03002723

p_int:  0.996228899

p_ni:  0.003771101

Score:  0.478

Data Source:  BioPlex,STRINGDB

REXO5

Tdark

Family:  Enzyme

Novelty:  0.8782494

p_int:  0.990400764

p_ni:  0.009599235

p_wrong:  2e-9

Score:  0.398

Data Source:  BioPlex,STRINGDB

USP4

Tchem

Family:  Enzyme

Novelty:  0.01101075

p_int:  0.9880193

p_ni:  0.011199328

p_wrong:  0.000781372

Score:  0.258

Data Source:  BioPlex,STRINGDB

POLR1E

Tbio

Family:  Enzyme

Novelty:  0.09991103

p_int:  0.981353269

p_ni:  0.018625795

p_wrong:  0.000020937

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (2)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
RNA adenylyltransferase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (15)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	3	4		95.2
basophil count	EFO_0005090	3	3	4		92.6
basophil percentage of leukocytes	EFO_0007992	1	2	2		83.8
systolic blood pressure	EFO_0006335	1	1	1		50.6
heel bone mineral density	EFO_0009270	1	2	2		44.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 15

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	4		95.2
basophil count	EFO_0005090	4		92.6
basophil percentage of leukocytes	EFO_0007992	2		83.8
systolic blood pressure	EFO_0006335	1		50.6
heel bone mineral density	EFO_0009270	2		44.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Disease mutation
Nucleotidyltransferase
Osteogenesis imperfecta
Polymorphism
Reference proteome
Repeat
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
Alzheimer's disease
basophil count
basophil percentage of leukocytes
BMI-adjusted waist circumference
breast carcinoma
granulocyte percentage of myeloid white cells
heel bone mineral density
lymphocyte percentage of leukocytes
monocyte count
monocyte percentage of leukocytes

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
craniofacial phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	family with sequence similarity 46 member A		693306
Mouse	family with sequence similarity 46, member A	MGI:2670964	212943
Dog	terminal nucleotidyltransferase 5A	VGNC:40681	481896
Horse	terminal nucleotidyltransferase 5A	VGNC:17873	100069784
Cow	terminal nucleotidyltransferase 5A	VGNC:28815	540234

Species	Name	OMA	EggNOG	Inparanoid
Macaque	family with sequence similarity 46 member A
Mouse	family with sequence similarity 46, member A
Dog	terminal nucleotidyltransferase 5A
Horse	terminal nucleotidyltransferase 5A
Cow	terminal nucleotidyltransferase 5A

Publication Statistics

PubMed Score 13.75

PubMed score by year

Reset Zoom

PubTator Score 6.97

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (27)

GeneRif Annotations (10)

Items per page:

10

0 of 0

PMID	Year	Title