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Tbio
TENT5A
Terminal nucleotidyltransferase 5A

Protein Summary
Description
Probable nucleotidyltransferase that may act as a non-canonical poly(A) RNA polymerase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320172
  • ENSP00000318298
  • ENSG00000112773
  • ENST00000369754
  • ENSP00000358769

Symbol
  • C6orf37
  • FAM46A
  • XTP11
  • OI18
  • XTP11
  • FAM46A
  • C6orf37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
microRNA
0.83
transcription factor binding site profile
0.81
gene perturbation
0.76
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.75   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
3
4
95.2
basophil count
3
3
4
92.6
basophil percentage of leukocytes
1
2
2
83.8
systolic blood pressure
1
1
1
50.6
heel bone mineral density
1
2
2
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
4
95.2
basophil count
4
92.6
basophil percentage of leukocytes
2
83.8
systolic blood pressure
1
50.6
heel bone mineral density
2
44.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 46 member A
693306
Mouse
MGI:2670964
212943
Dog
terminal nucleotidyltransferase 5A
VGNC:40681
481896
Horse
terminal nucleotidyltransferase 5A
VGNC:17873
100069784
Cow
terminal nucleotidyltransferase 5A
VGNC:28815
540234
Species
Name
OMA
EggNOG
Inparanoid
Macaque
family with sequence similarity 46 member A
Mouse
Dog
terminal nucleotidyltransferase 5A
Horse
terminal nucleotidyltransferase 5A
Cow
terminal nucleotidyltransferase 5A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96IP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (77)
1 – 10 of 77
FNDC3B
Tbio
Novelty:  0.03060075
p_int:  1
Score:  0.687
Data Source:  BioPlex,STRINGDB
FNDC3A
Tbio
Novelty:  0.04721453
p_int:  0.999999932
p_ni:  6.2e-8
p_wrong:  5e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
BCCIP
Tbio
Novelty:  0.02710491
p_int:  0.999913045
p_ni:  0.000086955
Score:  0.557
Data Source:  BioPlex,STRINGDB
DCAF6
Tbio
Novelty:  0.01269552
p_int:  0.999165367
p_ni:  0.000834633
Score:  0.479
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.998985883
p_ni:  0.001014116
p_wrong:  1e-9
Score:  0.299
Data Source:  BioPlex,STRINGDB
HDLBP
Tbio
Novelty:  0.00979636
p_int:  0.998461901
p_ni:  0.001538099
Score:  0.375
Data Source:  BioPlex,STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
p_int:  0.996228899
p_ni:  0.003771101
Score:  0.478
Data Source:  BioPlex,STRINGDB
REXO5
Tdark
Family:  Enzyme
Novelty:  0.8782494
p_int:  0.990400764
p_ni:  0.009599235
p_wrong:  2e-9
Score:  0.398
Data Source:  BioPlex,STRINGDB
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.9880193
p_ni:  0.011199328
p_wrong:  0.000781372
Score:  0.258
Data Source:  BioPlex,STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
p_int:  0.981353269
p_ni:  0.018625795
p_wrong:  0.000020937
Data Source:  BioPlex
Publication Statistics
PubMed Score  13.75

PubMed score by year
PubTator Score  6.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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