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Tdark
APOPT1
Apoptogenic protein 1, mitochondrial

Protein Summary
Description
Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade. This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409074
  • ENSP00000386485
  • ENSG00000256053

Symbol
  • APOP1
  • C14orf153
  • APOP
  • APOP1
  • C14orf153
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
transcription factor binding site profile
0.73
cellular component
0.68
tissue sample
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
CLUH
Tbio
Novelty:  0.14027296
p_int:  0.939080691
p_ni:  0.06091929
p_wrong:  1.9e-8
Score:  0.541
Data Source:  BioPlex,STRINGDB
DNTT
Tchem
Family:  Enzyme
Novelty:  0.00027411
Score:  0.63
Data Source:  STRINGDB
ABCB1
Tchem
Family:  Transporter
Novelty:  0.00018144
Score:  0.623
Data Source:  STRINGDB
ZNF180
Tdark
Family:  TF
Novelty:  0.26455119
Score:  0.493
Data Source:  STRINGDB
COX14
Tbio
Family:  Enzyme
Novelty:  0.09340462
Score:  0.492
Data Source:  STRINGDB
COA3
Tbio
Family:  Enzyme
Novelty:  0.04949473
Score:  0.481
Data Source:  STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
Score:  0.469
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.453
Data Source:  STRINGDB
PPP2R3A
Tbio
Family:  Enzyme
Novelty:  0.0350873
Score:  0.451
Data Source:  STRINGDB
SURF1
Tbio
Novelty:  0.00717605
Score:  0.43
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
3
4
91.4
heel bone mineral density
1
2
2
83.1
intelligence
7
9
3
6
82.3
serum gamma-glutamyl transferase measurement
1
1
1
77.3
7
4
2
1.1
77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
4
91.4
heel bone mineral density
2
83.1
intelligence
3
6
82.3
serum gamma-glutamyl transferase measurement
1
77.3
2
1.1
77
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915270
68020
Rat
RGD:1304719
299341
Dog
apoptogenic 1, mitochondrial
VGNC:53488
100687117
Horse
apoptogenic 1, mitochondrial
VGNC:15427
100059753
Cow
apoptogenic 1, mitochondrial
VGNC:26037
617441
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
apoptogenic 1, mitochondrial
Horse
apoptogenic 1, mitochondrial
Cow
apoptogenic 1, mitochondrial
Publication Statistics
PubMed Score 19.76
PubMed score by year
PubTator Score 4.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title