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Tdark
APOPT1
Apoptogenic protein 1, mitochondrial

Protein Summary
Description
Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade. This gene encodes a protein that localizes to the mitochondria, where it stimulates the release of cytochrome c, thereby promoting programmed cell death. Mutations in this gene have been found in individuals with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409074
  • ENSP00000386485
  • ENSG00000256053

Symbol
  • APOP1
  • C14orf153
  • APOP
  • APOP1
  • C14orf153
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
transcription factor binding site profile
0.73
cellular component
0.68
tissue sample
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.74   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.74   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (18)
1 – 10 of 18
CLUH
Tbio
Novelty: 0.13787182
p_int: 0.939080691
p_ni: 0.06091929
p_wrong: 1.9e-8
Score: 0.541
Data Source: BioPlex,STRINGDB
DNTT
Tchem
Family: Enzyme
Novelty: 0.00035023
Score: 0.63
Data Source: STRINGDB
ABCB1
Tchem
Family: Transporter
Novelty: 0.00022166
Score: 0.623
Data Source: STRINGDB
ZNF180
Tdark
Family: TF
Novelty: 1.18644068
Score: 0.493
Data Source: STRINGDB
COX14
Tbio
Family: Enzyme
Novelty: 0.13817305
Score: 0.492
Data Source: STRINGDB
COA3
Tbio
Family: Enzyme
Novelty: 0.08242837
Score: 0.481
Data Source: STRINGDB
ABCG2
Tchem
Family: Transporter
Novelty: 0.00035063
Score: 0.469
Data Source: STRINGDB
COX15
Tbio
Family: Enzyme
Novelty: 0.03868472
Score: 0.453
Data Source: STRINGDB
PPP2R3A
Tbio
Family: Enzyme
Novelty: 0.05471953
Score: 0.451
Data Source: STRINGDB
SURF1
Tbio
Novelty: 0.00865786
Score: 0.43
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.74

PubMed score by year
PubTator Score  4.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer