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Tbio
FBXL20
F-box/LRR-repeat protein 20

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264658
  • ENSP00000264658
  • ENSG00000108306
  • ENST00000394294
  • ENSP00000377832
  • ENST00000583610
  • ENSP00000462271

Symbol
  • FBL2
  • Fbl2
  • Fbl20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
cell type or tissue
0.77
disease perturbation
0.74
transcription factor
0.69
transcription factor binding site profile
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
3
88.3
creatinine measurement
3
3
3
83
mean corpuscular hemoglobin concentration
1
1
1
77.1
mean reticulocyte volume
1
1
1
56.7
mean corpuscular volume
1
1
1
52.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
88.3
creatinine measurement
3
83
mean corpuscular hemoglobin concentration
1
77.1
mean reticulocyte volume
1
56.7
mean corpuscular volume
1
52.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 20
VGNC:12134
454628
Macaque
F-box and leucine rich repeat protein 20
697394
Mouse
MGI:1919444
72194
Dog
F-box and leucine rich repeat protein 20
612832
Horse
F-box and leucine rich repeat protein 20
VGNC:52385
100068335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 20
Macaque
F-box and leucine rich repeat protein 20
Mouse
Dog
F-box and leucine rich repeat protein 20
Horse
F-box and leucine rich repeat protein 20
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96IG2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (331)
1 – 10 of 331
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.99996431
p_ni: 0.000001266
p_wrong: 0.000034424
Score: 0.961
Data Source: BioPlex,STRINGDB
YPEL3
Tbio
Novelty: 0.12550227
p_int: 0.999916159
p_ni: 0.000039504
p_wrong: 0.000044337
Score: 0.631
Data Source: BioPlex,STRINGDB
PVR
Tbio
Novelty: 0.00215811
p_int: 0.999012067
p_ni: 0.000389524
p_wrong: 0.000598409
Score: 0.177
Data Source: BioPlex,STRINGDB
YPEL1
Tbio
Novelty: 0.17068379
p_int: 0.998836045
p_ni: 0.000017885
p_wrong: 0.00114607
Score: 0.357
Data Source: BioPlex,STRINGDB
RABGGTB
Tbio
Family: Enzyme
Novelty: 0.06786314
p_int: 0.998696362
p_ni: 0.000372359
p_wrong: 0.000931278
Score: 0.467
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.966
Data Source: STRINGDB
FBXO11
Tbio
Novelty: 0.02762674
Score: 0.955
Data Source: STRINGDB
FBXL3
Tbio
Novelty: 0.05042679
Score: 0.951
Data Source: STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.942
Data Source: STRINGDB
FBXL8
Tdark
Novelty: 0.84091737
Score: 0.94
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.42

PubMed score by year
PubTator Score  3.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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