Tbio AJUBA LIM domain-containing protein ajuba

Protein Summary

Description

Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.

Uniprot Accession IDs

• Q96IF1
• A8MX18
• D3DS37

Gene Name

• AJUBA

Ensembl ID

• ENST00000262713
• ENSP00000262713
• ENSG00000129474
• ENST00000361265
• ENSP00000354491
• ENST00000397388
• ENSP00000380543

Symbol

• JUB
• JUB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
transcription factor binding site profile	0.91
small molecule perturbation	0.79
cellular component	0.76
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Lim Domain-containing Protein Ajuba

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Lim Domain-containing Protein Ajuba

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.9   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0