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Tbio
AJUBA
LIM domain-containing protein ajuba

Protein Summary
Description
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262713
  • ENSP00000262713
  • ENSG00000129474
  • ENST00000361265
  • ENSP00000354491
  • ENST00000397388
  • ENSP00000380543

Symbol
  • JUB
  • JUB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor binding site profile
0.91
small molecule perturbation
0.79
cellular component
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.01   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.01   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (228)
FBXO10
Tbio
Novelty:  0.18324932
p_int:  0.999999279
p_ni:  7.21e-7
Data Source:  BioPlex
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.999999221
p_ni:  7.78e-7
p_wrong:  1e-9
Score:  0.432
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999998277
p_ni:  0.000001706
p_wrong:  1.7e-8
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999986202
p_ni:  0.000013786
p_wrong:  1.3e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZNF576
Tdark
Family:  TF
Novelty:  13.18548387
p_int:  0.9999799
p_ni:  0.000020092
p_wrong:  8e-9
Score:  0.218
Data Source:  BioPlex,STRINGDB
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.760371367
p_ni:  0.000167963
p_wrong:  0.239460671
Data Source:  BioPlex
CDH1
Tbio
Novelty:  0.00010629
Score:  0.963
Data Source:  STRINGDB
BORA
Tbio
Novelty:  0.0374925
Score:  0.96
Data Source:  STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
Score:  0.956
Data Source:  Reactome,STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.951
Data Source:  STRINGDB
Pathways (20)
Activation of HOX genes during differentiation (R-HSA-5619507)

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Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to hypoxia
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cell Cycle
Cell Cycle, Mitotic
Cellular response to hypoxia
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
6
10
99.4
reticulocyte count
6
3
6
97
reticulocyte measurement
3
2
3
94.7
self reported educational attainment
4
4
3
5.7
91
mathematical ability
4
3
4
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
10
99.4
reticulocyte count
6
97
reticulocyte measurement
3
94.7
self reported educational attainment
3
5.7
91
mathematical ability
4
86.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ajuba LIM protein
VGNC:3505
452791
Macaque
ajuba LIM protein
712865
Mouse
MGI:1341886
16475
Rat
RGD:620407
85265
Dog
ajuba LIM protein
480244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ajuba LIM protein
Macaque
ajuba LIM protein
Mouse
Rat
Dog
ajuba LIM protein
Publication Statistics
PubMed Score 29.01
PubMed score by year
PubTator Score 24.43
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title