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Tdark
IGSF21
Immunoglobulin superfamily member 21

Protein Summary
Description
Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2. This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251296
  • ENSP00000251296
  • ENSG00000117154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
cell type or tissue
0.74
phenotype
0.68
transcription factor
0.67
tissue sample
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
72.6
viral load
1
1
1
64.9
smoking initiation
1
1
1
58.4
gut microbiome measurement
1
1
0
5.5
17.8
smoking cessation
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
72.6
viral load
1
64.9
smoking initiation
1
58.4
gut microbiome measurement
0
5.5
17.8
smoking cessation
1
14.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
immunoglobin superfamily member 21
VGNC:6883
456572
Macaque
immunoglobin superfamily member 21
701539
Mouse
MGI:2681842
230868
Rat
RGD:1310117
298591
Dog
immunoglobin superfamily member 21
VGNC:41914
478214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
immunoglobin superfamily member 21
Macaque
immunoglobin superfamily member 21
Mouse
Rat
Dog
immunoglobin superfamily member 21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96ID5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (38)
1 – 10 of 38
VPS13D
Tdark
Novelty:  0.12578583
Score:  0.73
Data Source:  STRINGDB
EMC1
Tbio
Novelty:  0.05360812
Score:  0.729
Data Source:  STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
Score:  0.69
Data Source:  STRINGDB
ADH7
Tchem
Family:  Enzyme
Novelty:  0.00488034
Score:  0.666
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.661
Data Source:  STRINGDB
CDK18
Tchem
Family:  Kinase
Novelty:  0.053383
Score:  0.65
Data Source:  STRINGDB
AKR7A2
Tbio
Family:  Enzyme
Novelty:  0.00917827
Score:  0.622
Data Source:  STRINGDB
KIF1A
Tbio
Novelty:  0.00505209
Score:  0.577
Data Source:  STRINGDB
SLC16A12
Tbio
Family:  Transporter
Novelty:  0.06883837
Score:  0.576
Data Source:  STRINGDB
WDR92
Tbio
Novelty:  55
Score:  0.575
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.92

PubMed score by year
PubTator Score  0.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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