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Tbio
SUCLG2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Protein Summary
Description
GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307227
  • ENSP00000307432
  • ENSG00000172340
  • ENST00000493112
  • ENSP00000419325

Symbol
  • G-SCS
  • GBETA
  • GTPSCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
molecular function
0.97
protein domain
0.92
histone modification site profile
0.87
kinase perturbation
0.84


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1073.87   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1073.87   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
SUCLG1
Tbio
Family:  Enzyme
Novelty:  0.01113643
p_int:  0.999476209
p_ni:  0.000523791
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
GALNT11
Tbio
Family:  Enzyme
Novelty:  0.09714947
p_int:  0.945009085
p_ni:  0.054990913
p_wrong:  2e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
ZNF146
Tbio
Family:  TF
Novelty:  0.05977172
p_int:  0.943004122
p_ni:  0.055949298
p_wrong:  0.001046579
Score:  0.232
Data Source:  BioPlex,STRINGDB
DNAJC12
Tbio
Novelty:  0.05214775
p_int:  0.893310976
p_ni:  0.05881313
p_wrong:  0.047875895
Score:  0.226
Data Source:  BioPlex,STRINGDB
SLC25A15
Tbio
Family:  Transporter
Novelty:  0.01122054
p_int:  0.756840818
p_ni:  0.243159047
p_wrong:  1.35e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
SDHA
Tbio
Family:  Enzyme
Novelty:  0.00223171
Score:  0.977
Data Source:  STRINGDB
SDHB
Tchem
Family:  Enzyme
Novelty:  0.0010199
Score:  0.955
Data Source:  STRINGDB
SDHC
Tbio
Family:  Enzyme
Novelty:  0.0005776
Score:  0.954
Data Source:  STRINGDB
SDHD
Tbio
Family:  Enzyme
Novelty:  0.00167904
Score:  0.943
Data Source:  STRINGDB
DLST
Tbio
Family:  Enzyme
Novelty:  0.01516932
Score:  0.941
Data Source:  STRINGDB
Pathways (14)
Citric acid cycle (TCA cycle) (R-HSA-71403)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
2
2
74.6
forced expiratory volume
1
1
1
64.9
beta-amyloid 1-42 measurement
1
1
1
53.7
mean corpuscular volume
1
1
1
42.3
self reported educational attainment
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
2
74.6
forced expiratory volume
1
64.9
beta-amyloid 1-42 measurement
1
53.7
mean corpuscular volume
1
42.3
self reported educational attainment
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
succinate-CoA ligase GDP-forming beta subunit
697454
Mouse
MGI:1306824
20917
Rat
RGD:1305008
362404
Dog
succinate-CoA ligase GDP-forming beta subunit
VGNC:46967
476562
Horse
succinate-CoA ligase GDP-forming beta subunit
VGNC:23744
100063955
Species
Name
OMA
EggNOG
Inparanoid
Macaque
succinate-CoA ligase GDP-forming beta subunit
Mouse
Rat
Dog
succinate-CoA ligase GDP-forming beta subunit
Horse
succinate-CoA ligase GDP-forming beta subunit
Publication Statistics
PubMed Score 1073.87
PubMed score by year
PubTator Score 174.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title