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Tbio
RCC1L
RCC1-like G exchanging factor-like protein

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for mitochondrial dynamin-related GTPase OPA1. Activates OPA1, by exchanging bound GDP for free GTP, and drives OPA1 and MFN1-dependent mitochondrial fusion (PubMed:28746876). Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system (PubMed:27667664). This gene encodes a protein containing regulator of chromosome condensation 1-like repeats. The encoded protein may function as a guanine nucleotide exchange factor. This gene is located in a region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610322
  • ENSP00000480364
  • ENSG00000274523
  • ENST00000614461
  • ENSP00000477659
  • ENST00000618035
  • ENSP00000480781

Symbol
  • WBSCR16
  • WBSCR16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
36.5
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96I51-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (70)
1 – 10 of 70
NME6
Tbio
Family:  Kinase
Novelty:  0.12087274
p_int:  0.999922317
p_ni:  0.000077683
p_wrong:  1e-9
Score:  0.413
Data Source:  BioPlex,STRINGDB
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.99846645
p_ni:  0.00153355
Score:  0.53
Data Source:  BioPlex,STRINGDB
CLPP
Tchem
Family:  Enzyme
Novelty:  0.00105289
p_int:  0.998210575
p_ni:  0.001789425
Data Source:  BioPlex
YARS2
Tbio
Family:  Enzyme
Novelty:  0.00522139
p_int:  0.979564141
p_ni:  0.020435859
Data Source:  BioPlex
RBM42
Tdark
Novelty:  0.37655036
p_int:  0.893388563
p_ni:  0.106611437
Score:  0.189
Data Source:  BioPlex,STRINGDB
DHH
Tbio
Novelty:  0.00329784
p_int:  0.887987485
p_ni:  0.112012515
Score:  0.269
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.770533316
p_ni:  0.229466684
Data Source:  BioPlex
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.774
Data Source:  STRINGDB
NEK6
Tchem
Family:  Kinase
Novelty:  0.02394134
Score:  0.758
Data Source:  STRINGDB
RPUSD3
Tdark
Family:  Enzyme
Novelty:  1.00226099
Score:  0.737
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.98

PubMed score by year
PubTator Score  0.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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