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Tdark
TMEM141
Transmembrane protein 141

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290079
  • ENSP00000290079
  • ENSG00000244187
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
histone modification site profile
0.73
tissue
0.58
transcription factor binding site profile
0.57
disease perturbation
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
UBA52
Tbio
Novelty:  0.01637744
p_int:  0.999992567
p_ni:  0.00000588
p_wrong:  0.000001552
Data Source:  BioPlex
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.934297585
p_ni:  0.0657022
p_wrong:  2.15e-7
Data Source:  BioPlex
HIGD1B
Tdark
Novelty:  0.30493093
Score:  0.833
Data Source:  STRINGDB
TMEM14A
Tbio
Novelty:  0.15995178
Score:  0.81
Data Source:  STRINGDB
HRCT1
Tdark
Novelty:  0.17217436
Score:  0.734
Data Source:  STRINGDB
HIGD1A
Tbio
Novelty:  0.06248108
Score:  0.724
Data Source:  STRINGDB
TMEM14C
Tdark
Novelty:  0.10707234
Score:  0.714
Data Source:  STRINGDB
IFI27L1
Tdark
Novelty:  0.7520707
Score:  0.58
Data Source:  STRINGDB
ANO5
Tbio
Novelty:  0.01237979
Score:  0.499
Data Source:  STRINGDB
THOC1
Tbio
Novelty:  0.03702557
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
51
corneal resistance factor
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
51
corneal resistance factor
1
38.2
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 141
VGNC:4878
748725
Mouse
MGI:1098773
51875
Rat
RGD:1561492
499755
Dog
transmembrane protein 141
VGNC:47477
607204
Cow
transmembrane protein 141
VGNC:35974
514305
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 141
Mouse
Rat
Dog
transmembrane protein 141
Cow
transmembrane protein 141
Publication Statistics
PubMed Score 1.19
PubMed score by year
PubTator Score 0.10
PubTator score by year
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Related Publications
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PMID
Year
Title