Tbio RBM17 Splicing factor 45

Protein Summary

Description

Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q96I25
• Q96GY6

Gene Name

• RBM17

Ensembl ID

• ENST00000379888
• ENSP00000369218
• ENSG00000134453
• ENST00000446108
• ENSP00000388638

Symbol

• SPF45
• SPF45

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
virus perturbation	0.94
transcription factor binding site profile	0.85
ligand (protein) perturbation	0.83
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Splicing Factor 45

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Splicing Factor 45

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.53   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.53   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (245)

Explore Interacting Targets

1 – 10 of 245

• See Interactions on String-DB

CHERP

Tbio

Novelty:  0.06955626

p_int:  0.999984457

p_ni:  0.000015543

Score:  0.99

Data Source:  BioPlex,STRINGDB

U2SURP

Tbio

Novelty:  0.17256196

p_int:  0.999976791

p_ni:  0.000023209

Score:  0.985

Data Source:  BioPlex,STRINGDB

ZRSR2P1

Tdark

Novelty:  0.0367357

p_int:  0.999841324

p_ni:  0.000046845

p_wrong:  0.000111831

Score:  0.702

Data Source:  BioPlex,STRINGDB

SFSWAP

Tdark

Novelty:  0.2236256

p_int:  0.999074751

p_ni:  0.000925248

Score:  0.352

Data Source:  BioPlex,STRINGDB

SF3A2

Tbio

Novelty:  0.03658692

p_int:  0.998721842

p_ni:  0.001277397

p_wrong:  7.61e-7

Score:  0.994

Data Source:  BioPlex,STRINGDB

RBM5

Tbio

Novelty:  0.01706857

p_int:  0.998551308

p_ni:  0.001448691

p_wrong:  1e-9

Score:  0.977

Data Source:  BioPlex,STRINGDB

GPATCH11

Tdark

Novelty:  0.86338046

p_int:  0.995440106

p_ni:  0.004559731

p_wrong:  1.63e-7

Score:  0.551

Data Source:  BioPlex,STRINGDB

SF3A3

Tbio

Novelty:  0.03815499

p_int:  0.995429797

p_ni:  0.004570203

Score:  0.978

Data Source:  BioPlex,STRINGDB

SF3A1

Tbio

Novelty:  0.03405702

p_int:  0.994219596

p_ni:  0.005780404

Score:  0.983

Data Source:  BioPlex,STRINGDB

ZRSR2

Tbio

Novelty:  0.03449891

p_int:  0.952829754

p_ni:  0.047170246

Score:  0.71

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

KEGG (1)

WikiPathways (1)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
Reactome	mRNA Splicing	188 targets	R-HSA-72172
Reactome	mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
Processing of Capped Intron-Containing Pre-mRNA	241 targets	R-HSA-72203
mRNA Splicing	188 targets	R-HSA-72172
mRNA Splicing - Major Pathway	180 targets	R-HSA-72163

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (2)

Processes (4)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (37)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 37

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	8	9	0	1.2	98.6
lymphocyte count	EFO_0004587	3	3	4		95.2
type I diabetes mellitus	EFO_0001359	3	4	0	1.6	95
asthma	EFO_0000270	7	4	0	1.1	92.7
interleukin 2 receptor antagonist measurement	EFO_0008332	1	2	2		91.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 37

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
multiple sclerosis	EFO_0003885	0	1.2	98.6
lymphocyte count	EFO_0004587	4		95.2
type I diabetes mellitus	EFO_0001359	0	1.6	95
asthma	EFO_0000270	0	1.1	92.7
interleukin 2 receptor antagonist measurement	EFO_0008332	2		91.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Isopeptide bond
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
adult onset asthma
allergic rhinitis
allergy
alopecia areata
asthma
atopic eczema
autoimmune thyroid disease
blood protein measurement
childhood onset asthma
Crohn's disease

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RNA binding motif protein 17	VGNC:5714	450286
Macaque	RNA binding motif protein 17		712996
Mouse	RNA binding motif protein 17	MGI:1924188	76938
Rat	RNA binding motif protein 17	RGD:1311208	291295
Dog	RNA binding motif protein 17	VGNC:45411	478014

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RNA binding motif protein 17
Macaque	RNA binding motif protein 17
Mouse	RNA binding motif protein 17
Rat	RNA binding motif protein 17
Dog	RNA binding motif protein 17

Publication Statistics

PubMed Score 22.53

PubMed score by year

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PubTator Score 11.23

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (9)

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PMID	Year	Title