You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RBM17
Splicing factor 45

Protein Summary
Description
Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379888
  • ENSP00000369218
  • ENSG00000134453
  • ENST00000446108
  • ENSP00000388638

Symbol
  • SPF45
  • SPF45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
virus perturbation
0.94
transcription factor binding site profile
0.85
ligand (protein) perturbation
0.83
transcription factor perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.62   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.62   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
latent autoimmune diabetes in adults
1
1
0
1.2
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
latent autoimmune diabetes in adults
0
1.2
4.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 17
VGNC:5714
450286
Macaque
RNA binding motif protein 17
712996
Mouse
MGI:1924188
76938
Rat
RGD:1311208
291295
Dog
RNA binding motif protein 17
VGNC:45411
478014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 17
Macaque
RNA binding motif protein 17
Mouse
Rat
Dog
RNA binding motif protein 17
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96I25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (245)
1 – 10 of 245
CHERP
Tbio
Novelty: 0.06955626
p_int: 0.999984457
p_ni: 0.000015543
Score: 0.99
Data Source: BioPlex,STRINGDB
U2SURP
Tbio
Novelty: 0.17256196
p_int: 0.999976791
p_ni: 0.000023209
Score: 0.985
Data Source: BioPlex,STRINGDB
ZRSR2P1
Tdark
Novelty: 0.0367357
p_int: 0.999841324
p_ni: 0.000046845
p_wrong: 0.000111831
Score: 0.702
Data Source: BioPlex,STRINGDB
SFSWAP
Tdark
Novelty: 0.2236256
p_int: 0.999074751
p_ni: 0.000925248
Score: 0.352
Data Source: BioPlex,STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
p_int: 0.998721842
p_ni: 0.001277397
p_wrong: 7.61e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
RBM5
Tbio
Novelty: 0.01706857
p_int: 0.998551308
p_ni: 0.001448691
p_wrong: 1e-9
Score: 0.977
Data Source: BioPlex,STRINGDB
GPATCH11
Tdark
Novelty: 0.86338046
p_int: 0.995440106
p_ni: 0.004559731
p_wrong: 1.63e-7
Score: 0.551
Data Source: BioPlex,STRINGDB
SF3A3
Tbio
Novelty: 0.03815499
p_int: 0.995429797
p_ni: 0.004570203
Score: 0.978
Data Source: BioPlex,STRINGDB
SF3A1
Tbio
Novelty: 0.03405702
p_int: 0.994219596
p_ni: 0.005780404
Score: 0.983
Data Source: BioPlex,STRINGDB
ZRSR2
Tbio
Novelty: 0.03449891
p_int: 0.952829754
p_ni: 0.047170246
Score: 0.71
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  20.62

PubMed score by year
PubTator Score  11.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer