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Tbio
SCLY
Selenocysteine lyase

Protein Classes
Protein Summary
Description
Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
protein domain
0.73
transcription factor binding site profile
0.66
tissue sample
0.65
virus perturbation
0.55


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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
91.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
selenocysteine lyase
VGNC:14172
460055
Macaque
selenocysteine lyase
695511
Mouse
MGI:1355310
50880
Rat
RGD:1359514
363285
Dog
selenocysteine lyase
477422
Species
Name
OMA
EggNOG
Inparanoid
Chimp
selenocysteine lyase
Macaque
selenocysteine lyase
Mouse
Rat
Dog
selenocysteine lyase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Selenoamino acid metabolism
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
ISCU
Tbio
Novelty: 0.0043097
Score: 0.966
Data Source: STRINGDB
SEPHS2
Tdark
Family: Enzyme
Novelty: 0.01657572
Score: 0.962
Data Source: STRINGDB
SEPHS1
Tbio
Family: Enzyme
Novelty: 0.01539662
Score: 0.958
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.925
Data Source: STRINGDB
TXNRD2
Tbio
Family: Enzyme
Novelty: 0.002052
Score: 0.906
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.856
Data Source: STRINGDB
GGCT
Tchem
Family: Enzyme
Novelty: 0.01154389
Score: 0.842
Data Source: STRINGDB
UAP1
Tbio
Family: Enzyme
Novelty: 0.02034314
Score: 0.825
Data Source: STRINGDB
LYRM4
Tbio
Novelty: 0.03319832
Score: 0.812
Data Source: STRINGDB
HSCB
Tbio
Novelty: 0.01330125
Score: 0.78
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.95

PubMed score by year
PubTator Score  64.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer