Tbio SCLY Selenocysteine lyase

Protein Summary

Description

Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium. Selenocysteine lyase (SCLY; EC 4.4.1.16) catalyzes the pyridoxal 5-prime phosphate-dependent conversion of L-selenocysteine to L-alanine and elemental selenium (Mihara et al., 2000 [PubMed 10692412]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q96I15
• B9A068
• J3KN06
• Q53SN1
• Q53SN8
• Q7L670
• Q9NVT7
• Q9NZR7
• hSCL

Gene Name

• SCLY

Ensembl ID

• ENST00000409736
• ENSP00000387162
• ENSG00000132330

Symbol

• SCL
• SCL
• hSCL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
protein domain	0.73
transcription factor binding site profile	0.66
tissue sample	0.65
virus perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Lyase / Selenocysteine Lyase

DTO Classes

Protein / Enzyme / Lyase / Selenocysteine Lyase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.37   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.37   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0