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Tbio
DDRGK1
DDRGK domain-containing protein 1

Protein Summary
Description
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (PubMed:28263186). The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354488
  • ENSP00000346483
  • ENSG00000198171

Symbol
  • C20orf116
  • UFBP1
  • UFBP1
  • SEMDSH
  • C20orf116
  • dJ1187M17.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.76
biological process
0.69
interacting protein
0.69
gene perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
CDK5RAP3
Tbio
Novelty:  0.03628071
p_int:  0.999999999
p_ni:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
UFL1
Tbio
Family:  Enzyme
Novelty:  0.02941148
p_int:  0.999999081
p_ni:  9.19e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
p_int:  0.99997518
p_ni:  0.00002482
Data Source:  BioPlex
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999560658
p_ni:  0.000143839
p_wrong:  0.000295503
Score:  0.211
Data Source:  BioPlex,STRINGDB
AKR7A3
Tbio
Family:  Enzyme
Novelty:  0.10681298
p_int:  0.998185228
p_ni:  0.001814772
Score:  0.178
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.991724483
p_ni:  0.008275517
Score:  0.216
Data Source:  BioPlex,STRINGDB
MYO18A
Tbio
Novelty:  0.05058328
p_int:  0.991509018
p_ni:  0.008490982
Data Source:  BioPlex
GRAMD2B
Tdark
Novelty:  0.55744753
p_int:  0.978521656
p_ni:  0.021478344
Data Source:  BioPlex
SRPRA
Tchem
Novelty:  0.01248718
p_int:  0.977113863
p_ni:  0.022886137
Score:  0.799
Data Source:  BioPlex,STRINGDB
UFC1
Tbio
Novelty:  0.04181639
p_int:  0.968842599
p_ni:  0.030836417
p_wrong:  0.000320984
Score:  0.921
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
2
2
78.7
household income
2
3
4
55.1
hematocrit
1
1
1
48.5
reticulocyte measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
78.7
household income
4
55.1
hematocrit
1
48.5
reticulocyte measurement
1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DDRGK domain containing 1
VGNC:6088
746946
Mouse
MGI:1924256
77006
Rat
RGD:1309979
296162
Dog
DDRGK domain containing 1
VGNC:39843
477173
Horse
DDRGK domain containing 1
VGNC:17082
100066678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DDRGK domain containing 1
Mouse
Rat
Dog
DDRGK domain containing 1
Horse
DDRGK domain containing 1
Publication Statistics
PubMed Score 14.07
PubMed score by year
PubTator Score 7.59
PubTator score by year
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Related Publications
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PMID
Year
Title