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Tbio
DIRAS2
GTP-binding protein Di-Ras2

Protein Summary
Description
Displays low GTPase activity and exists predominantly in the GTP-bound form. DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375765
  • ENSP00000364919
  • ENSG00000165023

Symbol
  • Di-Ras2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
molecular function
0.73
cell type or tissue
0.71
histone modification site profile
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
UNC13B
Tbio
Novelty: 0.00429808
p_int: 0.999997951
p_ni: 0.000002041
p_wrong: 8e-9
Score: 0.373
Data Source: BioPlex,STRINGDB
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.06140479
p_int: 0.999995446
p_ni: 0.000004554
Score: 0.69
Data Source: BioPlex,STRINGDB
ZNF581
Tdark
Family: TF
Novelty: 18
p_int: 0.997954797
p_ni: 0.002045146
p_wrong: 5.7e-8
Score: 0.232
Data Source: BioPlex,STRINGDB
SIRPD
Tdark
Novelty: 4.75114214
p_int: 0.982080654
p_ni: 0.017688993
p_wrong: 0.000230353
Score: 0.282
Data Source: BioPlex,STRINGDB
FTO
Tbio
Family: Enzyme
Novelty: 0.00053473
p_int: 0.867765855
p_ni: 0.132155519
p_wrong: 0.000078626
Score: 0.21
Data Source: BioPlex,STRINGDB
PIK3CB
Tchem
Family: Kinase
Novelty: 0.00390277
Score: 0.815
Data Source: STRINGDB
PRRT2
Tbio
Novelty: 0.00442931
Score: 0.704
Data Source: STRINGDB
C2CD2L
Tbio
Novelty: 0.2051681
Score: 0.675
Data Source: STRINGDB
LONRF2
Tdark
Family: Enzyme
Novelty: 1.01811251
Score: 0.663
Data Source: STRINGDB
SYNGR1
Tbio
Novelty: 0.08034637
Score: 0.647
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.13

PubMed score by year
PubTator Score  2.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer