You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

Protein Summary
Description
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317555
  • ENSP00000321503
  • ENSG00000247077
  • ENST00000498926
  • ENSP00000438465

Symbol
  • BXLBV68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
histone modification site profile
0.88
molecular function
0.76
cellular component
0.73
hub protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 47   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.37   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 47   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
FUNDC1
Tbio
Novelty:  0.02333176
Score:  0.97
Data Source:  Reactome,STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.964
Data Source:  STRINGDB
MLKL
Tchem
Family:  Kinase
Novelty:  0.00327224
Score:  0.963
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.91
Data Source:  STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.896
Data Source:  STRINGDB
RIPK3
Tchem
Family:  Kinase
Novelty:  0.00326006
Score:  0.856
Data Source:  STRINGDB
KEAP1
Tclin
Novelty:  0.00062812
Score:  0.834
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.773
Data Source:  STRINGDB
MARCH5
Tbio
Family:  Epigenetic
Novelty:  0.02702094
Score:  0.755
Data Source:  STRINGDB
FUNDC2
Tbio
Novelty:  0.09695817
Score:  0.641
Data Source:  STRINGDB
Pathways (31)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitophagy
Reactome
Receptor Mediated Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitophagy
Receptor Mediated Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
55.8
reticulocyte measurement
1
1
1
52.7
smoking status measurement
2
1
2
51.4
mean corpuscular volume
1
1
1
48.5
mean reticulocyte volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
55.8
reticulocyte measurement
1
52.7
smoking status measurement
2
51.4
mean corpuscular volume
1
48.5
mean reticulocyte volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
VGNC:8491
452388
Macaque
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
693782
Mouse
MGI:1919792
72542
Rat
RGD:1312028
288731
Dog
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
VGNC:52956
486221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Macaque
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Mouse
Rat
Dog
PGAM family member 5, mitochondrial serine/threonine protein phosphatase
Publication Statistics
PubMed Score 58.37
PubMed score by year
PubTator Score 19.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title