PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial
Protein Summary
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
- ENST00000317555
- ENSP00000321503
- ENSG00000247077
- ENST00000498926
- ENSP00000438465
- BXLBV68
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
histone modification site profile | 0.88 | ||
molecular function | 0.76 | ||
cellular component | 0.73 | ||
hub protein | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.37 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 47 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.37 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 47 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (31)
Reactome (5)
KEGG (3)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Macroautophagy | ||||
Reactome | Mitophagy | ||||
Reactome | Receptor Mediated Mitophagy | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Macroautophagy | ||||
Mitophagy | ||||
Receptor Mediated Mitophagy | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 2 | 2 | 55.8 | |||||
reticulocyte measurement | 1 | 1 | 1 | 52.7 | |||||
smoking status measurement | 2 | 1 | 2 | 51.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 48.5 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 55.8 | |||||
reticulocyte measurement | 1 | 52.7 | |||||
smoking status measurement | 2 | 51.4 | |||||
mean corpuscular volume | 1 | 48.5 | |||||
mean reticulocyte volume | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | VGNC:8491 | 452388 | |||||
Macaque | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | 693782 | ||||||
Mouse | MGI:1919792 | 72542 | ||||||
Rat | RGD:1312028 | 288731 | ||||||
Dog | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | VGNC:52956 | 486221 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | |||||
Macaque | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | |||||
Mouse | ||||||
Rat | ||||||
Dog | PGAM family member 5, mitochondrial serine/threonine protein phosphatase | |||||
Publication Statistics
PubMed Score 58.37
PubMed score by year
PubTator Score 19.36
PubTator score by year
Related Publications
Text Mined References (20)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
|---|