Tbio NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1

Protein Summary

Description

RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4.

Uniprot Accession IDs

• Q96HR8
• D3DP28
• E9PAZ2
• hNAF1

Gene Name

• NAF1

Ensembl ID

• ENST00000274054
• ENSP00000274054
• ENSG00000145414
• ENST00000422287
• ENSP00000408963

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.8
tissue sample	0.64
cell line	0.54
transcription factor perturbation	0.54
histone modification site profile	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 38   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.41   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0