You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TMEM176A
Transmembrane protein 176A

Protein Classes
Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000004103
  • ENSP00000004103
  • ENSG00000002933
  • ENST00000484928
  • ENSP00000417626

Symbol
  • HCA112
  • GS188
  • MS4B1
  • HCA112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
disease perturbation
0.95
kinase perturbation
0.76
small molecule perturbation
0.63
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.18   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
96.8
body height
1
1
1
13.7
hemoglobin measurement
1
1
1
3.9
hematocrit
1
1
1
3.9
anthropometric measurement
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
96.8
body height
1
13.7
hemoglobin measurement
1
3.9
hematocrit
1
3.9
anthropometric measurement
0
1.1
2.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 176A
VGNC:4540
463833
Mouse
MGI:1913308
66058
Rat
RGD:1310725
297077
Dog
transmembrane protein 176A
VGNC:47501
475535
Horse
transmembrane protein 176A
VGNC:24225
100063902
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 176A
Mouse
Rat
Dog
transmembrane protein 176A
Horse
transmembrane protein 176A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96HP8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (32)
1 – 10 of 32
TMEM176B
Tbio
Novelty: 0.02452255
Score: 0.982
Data Source: STRINGDB
MS4A14
Tdark
Novelty: 0.96793008
Score: 0.807
Data Source: STRINGDB
MS4A15
Tdark
Novelty: 1.87336215
Score: 0.777
Data Source: STRINGDB
MS4A8
Tdark
Novelty: 0.42717904
Score: 0.755
Data Source: STRINGDB
MS4A5
Tdark
Novelty: 0.47356151
Score: 0.75
Data Source: STRINGDB
TMEM98
Tbio
Novelty: 0.10281593
Score: 0.721
Data Source: STRINGDB
MS4A3
Tbio
Novelty: 0.05521485
Score: 0.72
Data Source: STRINGDB
MS4A4A
Tbio
Novelty: 0.10410193
Score: 0.717
Data Source: STRINGDB
MS4A12
Tdark
Novelty: 0.24047034
Score: 0.71
Data Source: STRINGDB
TMEM47
Tdark
Novelty: 0.1571161
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.18

PubMed score by year
PubTator Score  5.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer