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Tbio
SENP5
Sentrin-specific protease 5

Protein Classes
Protein Summary
Description
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323460
  • ENSP00000327197
  • ENSG00000119231
  • ENST00000445299
  • ENSP00000390231
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
kinase perturbation
0.91
disease perturbation
0.83
transcription factor perturbation
0.8
histone modification site profile
0.75


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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.36   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 5
VGNC:8852
471052
Macaque
SUMO1/sentrin specific peptidase 5
710223
Mouse
MGI:2443596
320213
Rat
RGD:1304604
303874
Dog
SUMO specific peptidase 5
VGNC:46007
488033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 5
Macaque
SUMO1/sentrin specific peptidase 5
Mouse
Rat
Dog
SUMO specific peptidase 5
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Processing and activation of SUMO
Reactome
SUMO is proteolytically processed
Reactome
SUMOylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Processing and activation of SUMO
SUMO is proteolytically processed
SUMOylation
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (68)
1 – 10 of 68
FEM1B
Tbio
Novelty: 0.06746412
p_int: 0.999821643
p_ni: 0.000178357
Data Source: BioPlex
CAMK2D
Tchem
Family: Kinase
Novelty: 0.02326864
p_int: 0.996818172
p_ni: 0.003181828
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.993462727
p_ni: 0.006536934
p_wrong: 3.39e-7
Data Source: BioPlex
HFE
Tbio
Novelty: 0.00042077
p_int: 0.990087167
p_ni: 0.009912832
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.98877864
p_ni: 0.011221359
Score: 0.306
Data Source: BioPlex,STRINGDB
MIS18A
Tbio
Novelty: 0.08143008
p_int: 0.982316478
p_ni: 0.017683522
Data Source: BioPlex
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
p_int: 0.980890251
p_ni: 0.019109748
Data Source: BioPlex
HCFC1
Tbio
Novelty: 0.00440762
p_int: 0.968005444
p_ni: 0.031994556
Data Source: BioPlex
CASQ2
Tbio
Novelty: 0.00775794
p_int: 0.962675839
p_ni: 0.037324161
Data Source: BioPlex
ZCCHC7
Tbio
Novelty: 0.01655453
p_int: 0.935561158
p_ni: 0.064438842
Score: 0.163
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.36

PubMed score by year
PubTator Score  10.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer