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Tbio
SFRP2
Secreted frizzled-related protein 2

Protein Summary
Description
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274063
  • ENSP00000274063
  • ENSG00000145423

Symbol
  • FRP2
  • SARP1
  • FRP-2
  • SARP1
  • SDF-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.99
molecular function
0.91
cell type or tissue
0.86
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.68   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.68   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.964004907
p_ni:  0.035995093
Score:  0.552
Data Source:  BioPlex,STRINGDB
MKLN1
Tbio
Novelty:  0.05014385
p_int:  0.95623689
p_ni:  0.04376311
Score:  0.552
Data Source:  BioPlex,STRINGDB
WNT1
Tbio
Novelty:  0.00124301
Score:  0.989
Data Source:  STRINGDB
WNT3A
Tchem
Novelty:  0.00119275
Score:  0.984
Data Source:  Reactome,STRINGDB
WNT8A
Tbio
Novelty:  0.01404009
Score:  0.971
Data Source:  STRINGDB
WNT8B
Tbio
Novelty:  0.0140304
Score:  0.971
Data Source:  STRINGDB
LRP5
Tbio
Novelty:  0.00089807
Score:  0.968
Data Source:  STRINGDB
LRP6
Tbio
Novelty:  0.00305615
Score:  0.959
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.925
Data Source:  STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
Score:  0.921
Data Source:  STRINGDB
Pathways (29)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (R-HSA-3772470)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (62)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 2
VGNC:10384
742398
Macaque
secreted frizzled related protein 2
699915
Mouse
MGI:108078
20319
Rat
RGD:735163
310552
Dog
secreted frizzled related protein 2
VGNC:46081
475471
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secreted frizzled related protein 2
Macaque
secreted frizzled related protein 2
Mouse
Rat
Dog
secreted frizzled related protein 2
Publication Statistics
PubMed Score 242.68
PubMed score by year
PubTator Score 150.48
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title