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Tdark
TMEM80
Transmembrane protein 80

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Target Illumination GWAS Analytics (TIGA)
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GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.45   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
0
1.2
90.4
intraocular pressure measurement
1
2
2
80.2
Keratoconus
1
1
1
77.9
2
2
0
1.2
46.9
waist-hip ratio
2
3
3
38.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
90.4
intraocular pressure measurement
2
80.2
Keratoconus
1
77.9
0
1.2
46.9
waist-hip ratio
3
38.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 80
VGNC:13387
450931
Mouse
MGI:1918698
71448
Rat
RGD:1308399
309109
Dog
transmembrane protein 80
VGNC:52053
483410
Horse
transmembrane protein 80
100146964
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 80
Mouse
Rat
Dog
transmembrane protein 80
Horse
transmembrane protein 80
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96HE8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (30)
1 – 10 of 30
ANO9
Tbio
Novelty:  0.16467408
Score:  0.635
Data Source:  STRINGDB
B9D1
Tbio
Novelty:  0.11567839
Score:  0.601
Data Source:  STRINGDB
CC2D2A
Tbio
Novelty:  0.03684487
Score:  0.598
Data Source:  STRINGDB
TMEM231
Tbio
Novelty:  0.17100188
Score:  0.594
Data Source:  STRINGDB
FCAMR
Tbio
Novelty:  0.05112165
Score:  0.587
Data Source:  STRINGDB
TMEM138
Tdark
Novelty:  0.40357932
Score:  0.566
Data Source:  STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
Score:  0.55
Data Source:  STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
Score:  0.548
Data Source:  STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
Score:  0.545
Data Source:  STRINGDB
CEP290
Tbio
Novelty:  0.00526375
Score:  0.537
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1.45

PubMed score by year
PubTator Score  0.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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