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Tbio
ERO1A
ERO1-like protein alpha

Protein Summary
Description
Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395686
  • ENSP00000379042
  • ENSG00000197930

Symbol
  • ERO1L
  • ERO1L
  • ERO1-L
  • ERO1LA
  • Ero1alpha
  • ERO1-alpha
  • ERO1-L-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.37   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.37   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
66.2
urinary metabolite measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
66.2
urinary metabolite measurement
1
57.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum oxidoreductase 1 alpha
VGNC:12628
452908
Macaque
endoplasmic reticulum oxidoreductase 1 alpha
708329
Mouse
MGI:1354385
50527
Rat
RGD:621713
171562
Dog
endoplasmic reticulum oxidoreductase 1 alpha
VGNC:40466
490691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum oxidoreductase 1 alpha
Macaque
endoplasmic reticulum oxidoreductase 1 alpha
Mouse
Rat
Dog
endoplasmic reticulum oxidoreductase 1 alpha
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96HE7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Insulin processing
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Insulin processing
Metabolism of proteins
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (55)
1 – 10 of 55
ERO1B
Tbio
Novelty:  0.06389159
p_int:  0.994468516
p_ni:  0.005531484
Score:  0.899
Data Source:  BioPlex,STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.984
Data Source:  STRINGDB
PDIA4
Tbio
Family:  Enzyme
Novelty:  0.01412168
Score:  0.956
Data Source:  STRINGDB
GPX8
Tbio
Family:  Enzyme
Novelty:  0.02304355
Score:  0.952
Data Source:  Reactome,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
Score:  0.947
Data Source:  Reactome,STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.918
Data Source:  Reactome,STRINGDB
PDIA3
Tbio
Family:  Enzyme
Novelty:  0.00285939
Score:  0.822
Data Source:  STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
Score:  0.793
Data Source:  STRINGDB
ERP44
Tbio
Novelty:  0.02352693
Score:  0.787
Data Source:  STRINGDB
TXNDC5
Tbio
Novelty:  0.02369481
Score:  0.78
Data Source:  STRINGDB
Publication Statistics
PubMed Score  103.37

PubMed score by year
PubTator Score  58.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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