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Tbio
ACY3
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)

Protein Summary
Description
Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255082
  • ENSP00000255082
  • ENSG00000132744

Symbol
  • ASPA2
  • ACY-3
  • HCBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
virus perturbation
0.68
transcription factor
0.56
tissue sample
0.52
cell line
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.44   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.44   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
58.2
urinary metabolite measurement
1
1
1
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
58.2
urinary metabolite measurement
1
58.2
Pathways (3)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Metabolism
Protein-Protein Interactions (10)
1 – 10 of 10
PMM2
Tchem
Family: Enzyme
Novelty: 0.01177513
Score: 0.808
Data Source: STRINGDB
ACY1
Tbio
Family: Enzyme
Novelty: 0.00912344
Score: 0.671
Data Source: STRINGDB
SHPK
Tbio
Family: Kinase
Novelty: 0.16166855
Score: 0.518
Data Source: STRINGDB
OAT
Tchem
Family: Enzyme
Novelty: 0.00125611
Score: 0.502
Data Source: STRINGDB
TBX10
Tbio
Family: TF
Novelty: 0.11869902
Score: 0.49
Data Source: STRINGDB
GORASP2
Tbio
Novelty: 0.02121907
Score: 0.48
Data Source: STRINGDB
LACTB2
Tbio
Family: Enzyme
Novelty: 0.1868172
Score: 0.457
Data Source: STRINGDB
RIMKLA
Tdark
Family: Enzyme
Novelty: 0.30213465
Score: 0.436
Data Source: STRINGDB
ASPA
Tbio
Family: Enzyme
Novelty: 0.02701619
Score: 0.418
Data Source: STRINGDB
SMTNL2
Tdark
Novelty: 0.33805653
Score: 0.409
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.44

PubMed score by year
PubTator Score  10.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer