Tbio PDLIM5 PDZ and LIM domain protein 5

Protein Summary

Description

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• Q96HC4
• A8K6F9
• D6RB78
• E9PBF5
• O60705
• Q56VN4
• Q5UW38
• Q8WVK0

Gene Name

• PDLIM5

Ensembl ID

• ENST00000317968
• ENSP00000321746
• ENSG00000163110
• ENST00000318007
• ENSP00000322021
• ENST00000359265
• ENSP00000352210
• ENST00000380180
• ENSP00000369527
• ENST00000503974
• ENSP00000424297
• ENST00000508216
• ENSP00000426804
• ENST00000514743
• ENSP00000424360
• ENST00000542407
• ENSP00000442187
• ENST00000615540
• ENSP00000480359

Symbol

• ENH
• L9
• ENH
• LIM
• ENH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
small molecule perturbation	0.93
transcription factor binding site profile	0.86
kinase perturbation	0.84
cellular component	0.82

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Pdz And Lim Domain Protein 5

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Pdz And Lim Domain Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.72   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 358   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 378.72   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0