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Tbio
PDLIM5
PDZ and LIM domain protein 5

Protein Summary
Description
May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity). This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317968
  • ENSP00000321746
  • ENSG00000163110
  • ENST00000318007
  • ENSP00000322021
  • ENST00000359265
  • ENSP00000352210
  • ENST00000380180
  • ENSP00000369527
  • ENST00000503974
  • ENSP00000424297
  • ENST00000508216
  • ENSP00000426804
  • ENST00000514743
  • ENSP00000424360
  • ENST00000542407
  • ENSP00000442187
  • ENST00000615540
  • ENSP00000480359

Symbol
  • ENH
  • L9
  • ENH
  • LIM
  • ENH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
small molecule perturbation
0.93
transcription factor binding site profile
0.86
kinase perturbation
0.84
cellular component
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.92   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 358   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.92   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 358   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
RWDD2B
Tdark
Novelty:  0.42452529
p_int:  0.99993842
p_ni:  0.00006158
Score:  0.795
Data Source:  BioPlex,STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.999905674
p_ni:  0.000094326
Score:  0.55
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999619716
p_ni:  0.000380284
Data Source:  BioPlex
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999555041
p_ni:  0.000444959
Score:  0.179
Data Source:  BioPlex,STRINGDB
NFATC2IP
Tbio
Novelty:  0.02974299
p_int:  0.996567499
p_ni:  0.003432501
Score:  0.542
Data Source:  BioPlex,STRINGDB
C6orf222
Tdark
Novelty:  37
p_int:  0.994970856
p_ni:  0.005029144
Data Source:  BioPlex
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.989797941
p_ni:  0.010202059
Data Source:  BioPlex
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.969693862
p_ni:  0.030306138
Data Source:  BioPlex
DENR
Tbio
Novelty:  0.00653432
p_int:  0.966636707
p_ni:  0.033363293
Score:  0.175
Data Source:  BioPlex,STRINGDB
METTL6
Tdark
Family:  Enzyme
Novelty:  0.43606491
p_int:  0.929207909
p_ni:  0.07079209
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Neurexins and neuroligins (R-HSA-6794361)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
90.8
mean platelet volume
3
3
3
87.4
heel bone mineral density
1
1
1
63.7
1
1
0
1.1
38.8
1
1
0
1.1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.8
mean platelet volume
3
87.4
heel bone mineral density
1
63.7
0
1.1
38.8
0
1.1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 5
VGNC:656
461385
Macaque
PDZ and LIM domain 5
705358
Mouse
MGI:1927489
56376
Rat
RGD:621076
64353
Dog
PDZ and LIM domain 5
VGNC:44387
478482
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 5
Macaque
PDZ and LIM domain 5
Mouse
Rat
Dog
PDZ and LIM domain 5
Publication Statistics
PubMed Score 257.92
PubMed score by year
PubTator Score 428.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title