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Tbio
TONSL
Tonsoku-like protein

Protein Summary
Description
Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409379
  • ENSP00000386239
  • ENSG00000160949
  • ENST00000647028
  • ENSP00000494329
  • ENSG00000285453

Symbol
  • IKBR
  • NFKBIL2
  • IKBR
  • NFKBIL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
histone modification site profile
0.87
protein domain
0.73
tissue sample
0.72
transcription factor binding site profile
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.08   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tonsoku like, DNA repair protein
VGNC:14604
464464
Macaque
tonsoku like, DNA repair protein
100430257
Mouse
MGI:1919999
72749
Rat
RGD:1307483
366953
Dog
tonsoku like, DNA repair protein
VGNC:47710
475127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tonsoku like, DNA repair protein
Macaque
tonsoku like, DNA repair protein
Mouse
Rat
Dog
tonsoku like, DNA repair protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96HA7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (57)
1 – 10 of 57
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999999552
p_ni:  4.48e-7
Score:  0.276
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999999436
p_ni:  5.64e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.999999052
p_ni:  9.48e-7
Score:  0.696
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999997825
p_ni:  0.000002174
Score:  0.739
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999991736
p_ni:  0.000008264
Score:  0.736
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.999989579
p_ni:  0.000010422
Data Source:  BioPlex
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999949832
p_ni:  0.000050169
Score:  0.824
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.999569596
p_ni:  0.000430404
Score:  0.186
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.988843668
p_ni:  0.0111338
p_wrong:  0.000022532
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.872353192
p_ni:  0.127623637
p_wrong:  0.000023171
Data Source:  BioPlex
Publication Statistics
PubMed Score  15.08

PubMed score by year
PubTator Score  8.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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