Tbio POM121 Nuclear envelope pore membrane protein POM 121

Protein Classes

PANTHER Classes

Protein / Structural Protein / Nuclear Envelope Pore Membrane Protein Pom 121

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121

Protein Summary

Description

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96HA1
• A6NFS9
• A8CDT4
• A8K933
• A8MXF9
• O75115
• Q96DI0
• Q9H9X1
• Q9Y2N3
• Q9Y4S7

Gene Name

• POM121

Ensembl ID

• ENST00000358357
• ENSP00000351124
• ENSG00000196313
• ENST00000395270
• ENSP00000378687
• ENST00000434423
• ENSP00000405562
• ENST00000446813
• ENSP00000393020
• ENST00000627934
• ENSP00000486504

Symbol

• KIAA0618
• NUP121
• POM121A
• P145
• POM121A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
co-expressed gene	0.94
tissue	0.88
virus perturbation	0.85
small molecule perturbation	0.79

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	1	1	1		72.9
alkaline phosphatase measurement	EFO_0004533	1	1	1		44.2
BMI-adjusted hip circumference	EFO_0008039	1	1	1		40.7
hip circumference	EFO_0005093	1	1	1		40.7
serum gamma-glutamyl transferase measurement	EFO_0004532	1	1	1		39.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
triglyceride measurement	EFO_0004530	1		72.9
alkaline phosphatase measurement	EFO_0004533	1		44.2
BMI-adjusted hip circumference	EFO_0008039	1		40.7
hip circumference	EFO_0005093	1		40.7
serum gamma-glutamyl transferase measurement	EFO_0004532	1		39.6

Reset Zoom  Beta Count   Odds Ratio

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	nuclear pore membrane protein 121	MGI:2137624	107939
Rat	POM121 transmembrane nucleoporin	RGD:620680	113975

Species	Name	OMA	EggNOG	Inparanoid
Mouse	nuclear pore membrane protein 121
Rat	POM121 transmembrane nucleoporin

Protein Structure (1 Structure, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96HA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (74)

Reactome (68)

KEGG (1)

WikiPathways (5)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Find Similar Targets

Items per page:

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Gene Ontology Terms (11)

Functions (2)

Components (6)

Processes (3)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
nuclear localization sequence binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural constituent of nuclear pore	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (174)

Explore Interacting Targets

1 – 10 of 174

• See Interactions on String-DB

ZNRF4

Tbio

Novelty:  0.16505328

p_int:  0.985265211

p_ni:  0.014734789

Data Source:  BioPlex

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.981913268

p_ni:  0.018086732

Data Source:  BioPlex

SPINT2

Tbio

Family:  Enzyme

Novelty:  0.0046602

p_int:  0.981267969

p_ni:  0.018732031

Data Source:  BioPlex

HFE

Tbio

Novelty:  0.00042077

p_int:  0.960636174

p_ni:  0.039363826

Data Source:  BioPlex

IL20RB

Tbio

Novelty:  0.01747619

p_int:  0.955661544

p_ni:  0.044338456

Score:  0.512

Data Source:  BioPlex,STRINGDB

CHRNA9

Tchem

Family:  IC

Novelty:  0.05009815

p_int:  0.920180182

p_ni:  0.079819818

Data Source:  BioPlex

PRMT2

Tbio

Family:  Epigenetic

Novelty:  0.04121581

p_int:  0.918189153

p_ni:  0.081810847

Data Source:  BioPlex

PCDHB16

Tdark

Novelty:  0.67206411

p_int:  0.90864181

p_ni:  0.09135819

Data Source:  BioPlex

SLC39A12

Tbio

Family:  Transporter

Novelty:  0.09127395

p_int:  0.907658991

p_ni:  0.092341008

Data Source:  BioPlex

JPH4

Tbio

Novelty:  0.07699598

p_int:  0.891217658

p_ni:  0.108782341

p_wrong:  1e-9

Data Source:  BioPlex

Publication Statistics

PubMed Score  53.33

PubMed score by year

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PubTator Score  49.65

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
mRNA transport
Nuclear pore complex
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
BMI-adjusted hip circumference
hip circumference
self reported educational attainment
serum gamma-glutamyl transferase measurement
triglyceride measurement

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging