Tbio POM121 Nuclear envelope pore membrane protein POM 121

Protein Summary

Description

Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q96HA1
• A6NFS9
• A8CDT4
• A8K933
• A8MXF9
• O75115
• Q96DI0
• Q9H9X1
• Q9Y2N3
• Q9Y4S7

Gene Name

• POM121

Ensembl ID

• ENST00000358357
• ENSP00000351124
• ENSG00000196313
• ENST00000395270
• ENSP00000378687
• ENST00000434423
• ENSP00000405562
• ENST00000446813
• ENSP00000393020
• ENST00000627934
• ENSP00000486504

Symbol

• KIAA0618
• NUP121
• POM121A
• P145
• POM121A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
co-expressed gene	0.94
tissue	0.88
virus perturbation	0.85
small molecule perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Structural Protein / Nuclear Envelope Pore Membrane Protein Pom 121

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nuclear Envelope Pore Membrane Protein Pom 121

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.29   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.29   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0