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Tbio
POM121
Nuclear envelope pore membrane protein POM 121

Protein Summary
Description
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358357
  • ENSP00000351124
  • ENSG00000196313
  • ENST00000395270
  • ENSP00000378687
  • ENST00000434423
  • ENSP00000405562
  • ENST00000446813
  • ENSP00000393020
  • ENST00000627934
  • ENSP00000486504

Symbol
  • KIAA0618
  • NUP121
  • POM121A
  • P145
  • POM121A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
co-expressed gene
0.94
tissue
0.88
virus perturbation
0.85
small molecule perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.33   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (174)
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.985265211
p_ni:  0.014734789
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.981913268
p_ni:  0.018086732
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.981267969
p_ni:  0.018732031
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.960636174
p_ni:  0.039363826
Data Source:  BioPlex
IL20RB
Tbio
Novelty:  0.01747619
p_int:  0.955661544
p_ni:  0.044338456
Score:  0.512
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.920180182
p_ni:  0.079819818
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.918189153
p_ni:  0.081810847
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.90864181
p_ni:  0.09135819
Data Source:  BioPlex
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.907658991
p_ni:  0.092341008
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.891217658
p_ni:  0.108782341
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (74)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cell Cycle
Cell Cycle, Mitotic
Cellular response to heat stress
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
72.9
alkaline phosphatase measurement
1
1
1
44.2
hip circumference
1
1
1
40.7
BMI-adjusted hip circumference
1
1
1
40.7
serum gamma-glutamyl transferase measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
72.9
alkaline phosphatase measurement
1
44.2
hip circumference
1
40.7
BMI-adjusted hip circumference
1
40.7
serum gamma-glutamyl transferase measurement
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 53.33
PubMed score by year
PubTator Score 49.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title