POM121
Nuclear envelope pore membrane protein POM 121
Protein Summary
Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
- ENST00000358357
- ENSP00000351124
- ENSG00000196313
- ENST00000395270
- ENSP00000378687
- ENST00000434423
- ENSP00000405562
- ENST00000446813
- ENSP00000393020
- ENST00000627934
- ENSP00000486504
- KIAA0618
- NUP121
- POM121A
- P145
- POM121A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.99 | ||
co-expressed gene | 0.94 | ||
tissue | 0.88 | ||
virus perturbation | 0.85 | ||
small molecule perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.33 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 63 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.33 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 63 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (174)
SPINT2
Family: Enzyme
Novelty: 0.0046602
p_int: 0.981267969
p_ni: 0.018732031
Data Source: BioPlex
IL20RB
Novelty: 0.01747619
p_int: 0.955661544
p_ni: 0.044338456
Score: 0.512
Data Source: BioPlex,STRINGDB
PRMT2
Family: Epigenetic
Novelty: 0.04121581
p_int: 0.918189153
p_ni: 0.081810847
Data Source: BioPlex
SLC39A12
Family: Transporter
Novelty: 0.09127395
p_int: 0.907658991
p_ni: 0.092341008
Data Source: BioPlex
Nearest Tclin Targets
Pathways (74)
Reactome (68)
KEGG (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 1 | 1 | 72.9 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 44.2 | |||||
hip circumference | 1 | 1 | 1 | 40.7 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 40.7 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 39.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 72.9 | |||||
alkaline phosphatase measurement | 1 | 44.2 | |||||
hip circumference | 1 | 40.7 | |||||
BMI-adjusted hip circumference | 1 | 40.7 | |||||
serum gamma-glutamyl transferase measurement | 1 | 39.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:2137624 | 107939 | ||||||
Rat | RGD:620680 | 113975 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 53.33
PubMed score by year
PubTator Score 49.65
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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