Tbio COQ2 4-hydroxybenzoate polyprenyltransferase, mitochondrial

Protein Summary

Description

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. This gene encodes an enzyme that functions in the final steps in the biosynthesis of CoQ (ubiquinone), a redox carrier in the mitochondrial respiratory chain and a lipid-soluble antioxidant. This enzyme, which is part of the coenzyme Q10 pathway, catalyzes the prenylation of parahydroxybenzoate with an all-trans polyprenyl group. Mutations in this gene cause coenzyme Q10 deficiency, a mitochondrial encephalomyopathy, and also COQ2 nephropathy, an inherited form of mitochondriopathy with primary renal involvement. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q96H96
• O95331
• Q1JQ78
• Q684R2
• 4-HB polyprenyltransferase

Gene Name

• COQ2

Ensembl ID

• ENST00000311469
• ENSP00000310873
• ENSG00000173085
• ENST00000439031
• ENSP00000409275

Symbol

• CL640
• MSA1
• CL640
• COQ10D1
• PHB:PPT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.88
transcription factor binding site profile	0.88
transcription factor perturbation	0.74
histone modification site profile	0.73
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / 4-hydroxybenzoate Polyprenyltransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / 4-hydroxybenzoate Polyprenyltransferase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.87   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.87   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0