Tbio CENPN Centromere protein N

Protein Summary

Description

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q96H22
• A8MZE6
• B3KN53
• B4DJD1
• B4DPY7
• C9JJM5
• D3DUK8
• E7ES30
• E7ETS3
• Q9NZ83
• CENP-N

Gene Name

• CENPN

Ensembl ID

• ENST00000299572
• ENSP00000299572
• ENSG00000166451
• ENST00000305850
• ENSP00000305608
• ENST00000393335
• ENSP00000377007
• ENST00000428963
• ENSP00000393991
• ENST00000439957
• ENSP00000395235

Symbol

• C16orf60
• ICEN32
• BM039
• CENP-N
• ICEN32
• C16orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor perturbation	0.84
transcription factor binding site profile	0.83
histone modification site profile	0.82
cellular component	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.27   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0