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Tbio
CENPN
Centromere protein N

Protein Summary
Description
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299572
  • ENSP00000299572
  • ENSG00000166451
  • ENST00000305850
  • ENSP00000305608
  • ENST00000393335
  • ENSP00000377007
  • ENST00000428963
  • ENSP00000393991
  • ENST00000439957
  • ENSP00000395235

Symbol
  • C16orf60
  • ICEN32
  • BM039
  • CENP-N
  • ICEN32
  • C16orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
histone modification site profile
0.82
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.24   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.24   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
2
3
88.4
protein measurement
1
1
1
63
blood metabolite measurement
1
1
1
63
amino acid measurement
1
1
1
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
3
88.4
protein measurement
1
63
blood metabolite measurement
1
63
amino acid measurement
1
63
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centromere protein N
VGNC:13683
454265
Macaque
centromere protein N
713624
Mouse
MGI:1919405
72155
Rat
RGD:1310953
361416
Dog
centromere protein N
VGNC:39109
479635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centromere protein N
Macaque
centromere protein N
Mouse
Rat
Dog
centromere protein N
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96H22-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (257)
1 – 10 of 257
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
p_int: 0.999906591
p_ni: 0.00009303
p_wrong: 3.79e-7
Data Source: BioPlex
PCDHGB1
Tdark
Novelty: 0.60440805
p_int: 0.998261505
p_ni: 0.001738491
p_wrong: 3e-9
Data Source: BioPlex
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.992867868
p_ni: 0.007132112
p_wrong: 2e-8
Data Source: BioPlex
KNOP1
Tdark
Novelty: 0.5609503
p_int: 0.989575122
p_ni: 0.007406057
p_wrong: 0.003018821
Data Source: BioPlex
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.975609461
p_ni: 0.023341476
p_wrong: 0.001049064
Data Source: BioPlex
ZNF71
Tdark
Family: TF
Novelty: 0.24703192
p_int: 0.960463917
p_ni: 0.026463011
p_wrong: 0.013073072
Data Source: BioPlex
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.958703574
p_ni: 0.040072841
p_wrong: 0.001223585
Data Source: BioPlex
CNBP
Tbio
Novelty: 0.00404247
p_int: 0.958342103
p_ni: 0.01208868
p_wrong: 0.029569217
Data Source: BioPlex
PCDHA12
Tdark
Novelty: 0.71618264
p_int: 0.954516923
p_ni: 0.045482645
p_wrong: 4.32e-7
Data Source: BioPlex
PCDHGB4
Tdark
Novelty: 0.25018904
p_int: 0.93864802
p_ni: 0.048657428
p_wrong: 0.012694552
Data Source: BioPlex
Publication Statistics
PubMed Score  12.24

PubMed score by year
PubTator Score  7.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer